IRAK-4 inhibitors.: Part III:: A series of imidazo[1,2-a] pyridines

被引：51
|
作者：
Buckley, George M. [1 ]
Fosbeary, Richard [1 ]
Fraser, Joanne L. [1 ]
Gowers, Lewis [1 ]
Higueruelo, Alicia P. [1 ]
James, Lynwen A. [1 ]
Jenkins, Kerry [1 ]
Mack, Stephen R. [1 ]
Morgan, Trevor [1 ]
Parry, David M. [1 ]
Pitt, William R. [1 ]
Rausch, Oliver [1 ]
Richard, Marianna D. [1 ]
Sabin, Verity [1 ]
机构：
[1] UCB, Cambridge CB21 6GS, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 12期
关键词：
IRAK; IRAK-4; inhibitor; kinase; kinase inhibitor; imidazo[1,2-a] pyridine; inflammation; anti-inflammatory; ligand efficiency; IL-1; TNF-alpha; TNF alpha; immunity;
D O I：
10.1016/j.bmcl.2008.04.042
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a] pyridino-pyridines and benzimidazolo-pyridines was explored. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3656 / 3660
页数：5
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