Role of lysophosphatidic acid and its receptors in the kidney

被引：22
作者：
Park, Frank [1 ]
Miller, Duane D. [1 ]
机构：
[1] Univ Tennessee, Ctr Hlth Sci, Coll Pharm, Dept Pharmaceut Sci, Memphis, TN 38163 USA
来源：
PHYSIOLOGICAL GENOMICS | 2017年 / 49卷 / 11期
关键词：
kidney; lysophosphatidic acid; G protein-coupled receptors; acute kidney injury; chronic kidney disease; autotaxin; phospholipids; TISSUE GROWTH-FACTOR; PROTEIN-COUPLED RECEPTOR; UNILATERAL URETERAL OBSTRUCTION; LIPID PHOSPHATE PHOSPHATASES; ISCHEMIA-REPERFUSION INJURY; DIABETIC-NEPHROPATHY; DIVERSE FUNCTIONS; MESANGIAL CELLS; BLOOD-PRESSURE; ACTIVATION;
D O I：
10.1152/physiolgenomics.00070.2017
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lysophosphatidic acid (LPA) is a bioactive phospholipid that can exert diverse biological effects in various diseased states of the kidney by activating at least six cognate G protein-coupled receptors and its complex network of heterotrimeric G proteins. In many models of acute and chronic kidney injury, pathological elevations in LPA promotes abnormal changes in renal tubular epithelial cell architecture by activating apoptotic signaling, recruits immune cells to the site of injury, and stimulates profibrotic signaling by increasing gene transcription. In renal cancers, LPA can promote vascular cell proliferation and tumor cell invasion. In this review, a summary will be provided to describe the involvement of LPA, its synthetic enzymes, and its associated receptors in normal and diseased kidneys. Further elucidation of the LPA system may open new doors in developing a lipid-receptor therapeutic platform for kidney diseases.
引用
收藏
页码：659 / 666
页数：8
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