'Childhood systemic mastocytosis associated with t(8;21) (q22; q22) acute myeloid leukemia'

被引：5

作者：

Rabade, Nikhil ^{[1
]}

Tembhare, Prashant ^{[1
]}

Patkar, Nikhil ^{[1
]}

Amare, Pratibha ^{[2
]}

Arora, Brijesh ^{[3
]}

Subramanian, P. G. ^{[1
]}

Gujral, Sumeet ^{[1
]}

机构：

[1] Tata Mem Hosp, Hematopathol Lab, Dept Pathol, Bombay, Maharashtra, India

[2] Tata Mem Hosp, Dept Canc Cytogenet, Bombay, Maharashtra, India

[3] Tata Mem Hosp, Dept Pediat Oncol, Bombay, Maharashtra, India

来源：

INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY | 2016年 / 59卷 / 03期

关键词：

Acute myeloid leukemia; mastocytosis; minimal residual disease;

D O I：

10.4103/0377-4929.188140

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Systemic mastocytosis (SM) with associated clonal nonmast cell lineage disease is seen in up to 20% cases of SM. SM is uncommon in the pediatric population. T (8; 21) (q22; q22) is a good prognostic factor in acute myeloid leukemia (AML). However, the presence of SM confers poor prognosis in t (8; 21) (q22; q22) associated AML. We report the case of a child with t (8; 21) (q22; q22) associated AML with SM and her minimal residual disease status over the course of her treatment. In our case, the abnormal mast cells, showing co-expression of CD25 and CD2, persisted even after the marrow showed no evidence of residual AML.

引用

页码：407 / 409

页数：3

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