'Childhood systemic mastocytosis associated with t(8;21) (q22; q22) acute myeloid leukemia'

被引：5
|
作者：
Rabade, Nikhil [1 ]
Tembhare, Prashant [1 ]
Patkar, Nikhil [1 ]
Amare, Pratibha [2 ]
Arora, Brijesh [3 ]
Subramanian, P. G. [1 ]
Gujral, Sumeet [1 ]
机构：
[1] Tata Mem Hosp, Hematopathol Lab, Dept Pathol, Bombay, Maharashtra, India
[2] Tata Mem Hosp, Dept Canc Cytogenet, Bombay, Maharashtra, India
[3] Tata Mem Hosp, Dept Pediat Oncol, Bombay, Maharashtra, India
来源：
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY | 2016年 / 59卷 / 03期
关键词：
Acute myeloid leukemia; mastocytosis; minimal residual disease;
D O I：
10.4103/0377-4929.188140
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Systemic mastocytosis (SM) with associated clonal nonmast cell lineage disease is seen in up to 20% cases of SM. SM is uncommon in the pediatric population. T (8; 21) (q22; q22) is a good prognostic factor in acute myeloid leukemia (AML). However, the presence of SM confers poor prognosis in t (8; 21) (q22; q22) associated AML. We report the case of a child with t (8; 21) (q22; q22) associated AML with SM and her minimal residual disease status over the course of her treatment. In our case, the abnormal mast cells, showing co-expression of CD25 and CD2, persisted even after the marrow showed no evidence of residual AML.
引用
收藏
页码：407 / 409
页数：3
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