Catalytic Asymmetric Intramolecular Hydroacylation with Rhodium/Phosphoramidite-Alkene Ligand Complexes

被引：74
|
作者：
Hoffman, Thomas J. [1 ]
Carreira, Erick M. [1 ]
机构：
[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 45期
关键词：
asymmetric catalysis; cyclopentanone; hydroacylation; P ligands; rhodium; CHIRAL DIENE LIGANDS; ENANTIOSELECTIVE CONJUGATE ADDITION; PHOSPHINE-OLEFIN COMPLEXES; TRANSITION-METAL CATALYSIS; PRIMARY ALLYLIC AMINES; STEERING LIGANDS; HOMOGENEOUS CATALYSIS; RHODIUM COMPLEXES; HIGH-PERFORMANCE; ORGANOSILICON COMPOUNDS;
D O I：
10.1002/anie.201104595
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Give me a P: An asymmetric intramolecular Rh-catalyzed hydroacylation reaction of pent-4-enals for the preparation of functionalized cyclopentanones in good yield and high enantioselectivity is described (see scheme, DCE=dichloroethane). This process uses rhodium complexes featuring novel modular phosphoramidite-alkene ligands and achiral phosphine coligands. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码：10670 / 10674
页数：5
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