Nanoparticles act as protein carriers during cellular internalization

被引：35
作者：
Doorley, Gerard W. [1 ]
Payne, Christine K.
机构：
[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 24期
关键词：
GOLD NANOPARTICLES; QUANTUM DOTS; SCAVENGER RECEPTORS; LINE RLE-6TN; FITC-ALBUMIN; ENDOCYTOSIS; THERAPY; CANCER; BIOLOGY; PROBES;
D O I：
10.1039/c2cc16937a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two-colour fluorescence microscopy was used to track the cellular internalization of nanoparticles exposed to extracellular serum proteins. Single particle tracking revealed that nanoparticles and serum proteins are internalized and transported through the cell as a single complex. This study demonstrates the importance of nanoparticle-protein interactions in cellular applications.
引用
收藏
页码：2961 / 2963
页数：3
相关论文
共 39 条
[1]  
Alberts B., 1994, MOL BIOL CELL
[2]   Quantum dots as cellular probes [J].
Alivisatos, AP ;
Gu, WW ;
Larabell, C .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2005, 7 :55-76
[3]   Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects [J].
Alkilany, Alaaldin M. ;
Nagaria, Pratik K. ;
Hexel, Cole R. ;
Shaw, Timothy J. ;
Murphy, Catherine J. ;
Wyatt, Michael D. .
SMALL, 2009, 5 (06) :701-708
[4]   The human plasma proteome - History, character, and diagnostic prospects [J].
Anderson, NL ;
Anderson, NG .
MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (11) :845-867
[5]   Detailed identification of plasma proteins adsorbed on copolymer nanoparticles [J].
Cedervall, Tommy ;
Lynch, Iseult ;
Foy, Martina ;
Berggard, Tord ;
Donnelly, Seamas C. ;
Cagney, Gerard ;
Linse, Sara ;
Dawson, Kenneth A. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (30) :5754-5756
[6]   Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles [J].
Cedervall, Tommy ;
Lynch, Iseult ;
Lindman, Stina ;
Berggard, Tord ;
Thulin, Eva ;
Nilsson, Hanna ;
Dawson, Kenneth A. ;
Linse, Sara .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (07) :2050-2055
[7]   Inorganic nanoparticle-based contrast agents for molecular imaging [J].
Cho, Eun Chul ;
Glaus, Charles ;
Chen, Jingyi ;
Welch, Michael J. ;
Xia, Younan .
TRENDS IN MOLECULAR MEDICINE, 2010, 16 (12) :561-573
[8]   Regulated portals of entry into the cell [J].
Conner, SD ;
Schmid, SL .
NATURE, 2003, 422 (6927) :37-44
[9]   Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology [J].
Daniel, MC ;
Astruc, D .
CHEMICAL REVIEWS, 2004, 104 (01) :293-346
[10]   Nanoparticle therapeutics: an emerging treatment modality for cancer [J].
Davis, Mark E. ;
Chen, Zhuo ;
Shin, Dong M. .
NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (09) :771-782
1234