Plasmacytoid dendritic cells - In search of their niche in immune responses

被引：15

作者：

Barchet, W ^{[1
]}

Blasius, A ^{[1
]}

Cella, M ^{[1
]}

Colonna, M ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

IMMUNOLOGIC RESEARCH | 2005年 / 32卷 / 1-3期

关键词：

virus; interferon; interferon-producing cell; plasmacytoid dendritic cell; toll-like receptor; chemokine;

D O I：

10.1385/IR:32:1-3:075

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing evidence that pDCs are a distinct cell type in the innate immune system. This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses.

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页码：75 / 83

页数：9

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