Plasmacytoid dendritic cells - In search of their niche in immune responses

被引：15
作者：
Barchet, W [1 ]
Blasius, A [1 ]
Cella, M [1 ]
Colonna, M [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
来源：
IMMUNOLOGIC RESEARCH | 2005年 / 32卷 / 1-3期
关键词：
virus; interferon; interferon-producing cell; plasmacytoid dendritic cell; toll-like receptor; chemokine;
D O I：
10.1385/IR:32:1-3:075
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing evidence that pDCs are a distinct cell type in the innate immune system. This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses.
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收藏
页码：75 / 83
页数：9
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