Role of MicroRNAs in Prostate Cancer Pathogenesis

被引：37

作者：

Wang, You-Lin ^{[1
]}

Wu, Shuai ^{[1
]}

Jiang, Bo ^{[1
]}

Yin, Fu-Fen ^{[2
]}

Zheng, Shuai-Shuai ^{[1
]}

Hou, Si-Chuan ^{[1
]}

机构：

[1] Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Urol, Qingdao 266071, Shandong, Peoples R China

[2] Qingdao Univ, Dept Obstet & Gynecol, Affiliate Hosp, Qingdao 266071, Shandong, Peoples R China

来源：

CLINICAL GENITOURINARY CANCER | 2015年 / 13卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Androgen; Apoptosis; Cancer stem cells; Epithelial to mesenchymal transition; Metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; RECEPTOR TRANSCRIPTIONAL ACTIVITY; UP-REGULATED MICRORNA-143; STEM-CELL PROPERTIES; ANDROGEN RECEPTOR; TUMOR-SUPPRESSOR; NEGATIVE FEEDBACK; DNA METHYLATION; DOWN-REGULATION; METASTASIS;

D O I：

10.1016/j.clgc.2015.01.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer (PCa) remains the most commonly diagnosed malignant tumor in men, and is the second highest cause of cancer mortality after lung tumors in the United States. Accumulating research indicates that microRNAs (miRNAs) are increasingly being implicated in PCa. miRNAs are conserved small noncoding RNAs that control gene expression posttranscriptionally. Recent profiling research suggests that miRNAs are aberrantly expressed in PCa, and these have been implicated in the regulation of apoptosis, cell cycle, epithelial to mesenchymal transition, PCa stem cells, and androgen receptor pathway. All of these might provide the basis for new approaches for PCa. Here, we review current findings regarding miRNA research in PCa to provide a strong basis for future study aimed at promising contributions of miRNA in PCa. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：261 / 270

页数：10

共 138 条

[1]

[Anonymous], UROL ONCOL

[2] MicroRNA-4723 Inhibits Prostate Cancer Growth through Inactivation of the Abelson Family of Nonreceptor Protein Tyrosine Kinases [J].