MicroRNA-143/-145 in Cardiovascular Diseases

被引：74

作者：

Zhao, Wang ^{[1
]}

Zhao, Shui-Ping ^{[1
]}

Zhao, Yu-Hong ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

SMOOTH-MUSCLE-CELLS; MICRORNA THERAPEUTICS; CIRCULATING MICRORNAS; DIAGNOSTIC BIOMARKERS; SENSITIVE MICRORNAS; PERIPHERAL-BLOOD; HEART-FAILURE; MIR-145; EXPRESSION; TARGETS;

D O I：

10.1155/2015/531740

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145.

引用

页数：9

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