Expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma tissues and clinical significance

被引：20
作者：
Yu, Bin [1 ]
Cai, Hongzhou [1 ]
Xu, Zicheng [1 ]
Xu, Ting [1 ]
Zou, Qing [1 ]
Gu, Min [2 ]
机构：
[1] Nanjing Med Univ, Dept Urol, Affiliated Canc Hosp Jiangsu Prov, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Dept Urol, Affiliated Hosp 1, Nanjing 210000, Jiangsu, Peoples R China
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 08期
关键词：
Expression; gene; renal cell carcinoma; transcription; EMBRYONIC STEM; LUNG-CANCER; PLURIPOTENCY; MARKER; DIFFERENTIATION; SIGNATURE; TUMORS; GENE;
D O I：
10.3109/21691401.2015.1105238
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We aimed to detect the expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma (RCC) tissues. Nanog and Oct4 mRNA expressions in RCC tissues significantly exceeded those in paracancerous tissues (p<0.01 and p<0.05), being positively correlated with histological grade (p<0.01 and p<0.05) and TNM stage (p<0.05). With increasing TNM stage (p<0.01) and lymphatic metastasis (p<0.05), the positive expression rate of Nanog protein increased. RCC patients with low Nanog and Oct4 expressions in tumor tissues had significantly higher survival rates (p<0.05). High Nanog and Oct4 expressions may be potential therapeutic targets.
引用
收藏
页码：1818 / 1823
页数：6
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