Catalytic enantioselective addition of nitro compounds to imines -: A simple approach for the synthesis of optically active β-nitro-α-amino esters

被引：2

作者：

Nishiwaki, N ^{[1
]}

Knudsen, KR ^{[1
]}

Gothelf, KV ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Ctr Met Catalyzed React, DK-8000 Aarhus C, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 16期

关键词：

amino acids; asymmetric catalysis; imines; Lewis acids; nitro compounds;

D O I：

10.1002/1521-3773(20010817)40:16<2992::AID-ANIE2992>3.0.CO;2-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalytic and asymmetric nitro-Mannich reaction of nitro compounds to α-imino esters catalyzed by chiral bisoxazoline-copper complexes [Eq. (1); Pg = protecting group] gave β-nitro-α-amino esters with excellent diastereo- and enantioselectivities. The reactions can be performed under ambient conditions.

引用

页码：2992 / 2995

页数：4

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