Transition Metal Catalyst-Free C-3 Sulfonylmethylation of Imidazo[1,2-a]pyridines with Glyoxylic Acid and Sodium Sulfinates in Water

被引：12

作者：

Chen, Jiewen ^{[1
]}

Wen, Kangmei ^{[1
]}

Wu, Yinrong ^{[1
]}

Shi, Jie ^{[1
]}

Yao, Xingang ^{[1
]}

Tang, Xiaodong ^{[1
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 05期

关键词：

TRIFLUOROMETHYLATION; IMIDAZOHETEROCYCLES; IMIDAZOPYRIDINES; SULFONYLATION; ARYLATION; BROMIDES; ALKENYL; ARYL;

D O I：

10.1021/acs.joc.1c02856

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe an efficient and benign protocol for direct C-3 sulfonylmethylation of imidazo[1,2-a]pyridines with glyoxylic acid and sodium sulfinates. Various sulfonylmethylated imidazo[1,2-a]pyridines were synthesized in water under transition metal catalyst-free conditions. This multicomponent reaction featured available substrates, good functional group tolerance, moderate to excellent yields, and mild reaction conditions.

引用

收藏

页码：3780 / 3787

页数：8

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