A convenient one-pot synthesis of 4-hydroxycoumarin, 4-hydroxythiocoumarin, and 4-hydroxyquinolin-2(1H)-one

被引：117

作者：

Jung, JC ^{[1
]}

Jung, YJ ^{[1
]}

Park, OS ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Nat Sci, Dept Chem, Cheongju 361763, Chungbuk, South Korea

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 08期

关键词：

D O I：

10.1081/SCC-100104003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved one-pot synthesis of 4-hydroxycoumarin. 4-hydroxythiocoumarin, and 4-hydroxyquinolin-2(1H)-one from 2-hydroxyacetophenone, 2-mercaptoacetophenone, and 2-aminoacetophenone, respectively, is described. The synthetic strategies involve the acylation and internal ring cyclization. This method is readily amenable to large-scale synthesis of 4-hydroxycoumarin, 4-hydroxythiocoumarin, and 4-hydroxyquinolin-2(1H)-one derivatives in high yields.

引用

页码：1195 / 1200

页数：6

共 23 条

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