Canine atopic dermatitis:: A genetic disease?

被引：0

作者：

Prelaud, Pascal ^{[1
]}

机构：

[1] Diplome Coll Europeen Dermatol Vet, Cin Advetia, DESV Dermatol, F-75012 Paris, France

来源：

BULLETIN DE L ACADEMIE VETERINAIRE DE FRANCE | 2007年 / 160卷 / 03期

关键词：

atopic dermatitis; dog; genes;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Canine atopic dermatitis is defined as a pruritic dermatitis associated with a genetic predisposition to develop allergic reactions against environmental allergens. There is a strong breed predisposition, with variations in clinical phenotypes. Few studies have been done on the genetic basis of canine atopic dermatitis. The use of consensual diagnostic criteria will help the development of genetic research. Canine atopic dermatitis provides an interesting animal model for genetic studies, since dogs do not suffer from other chronic allergic diseases or psoriasis. Genomic screening is helped by the homogeneity of dog breeds, and by the prevalence of atopic dermatitis in certain breeds, such as French bulldogs, West Highland White Terriers, or Labrador Retrievers. It is now possible to study the polymorphism of certain genes in dogs coding for molecules involved in non-specific cutaneous defence mechanisms (toll-like receptors, corneocyte differentiation proteins...).

引用

页码：229 / 234

页数：6

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