Dietary vitamin C and E modulates oxidative stress induced-kidney and lens injury in diabetic aged male rats through modulating glucose homeostasis and antioxidant systems

被引：56

作者：

Ozkaya, Dilek ^{[2
]}

Naziroglu, Mustafa ^{[1
]}

Armagan, Abdullah ^{[3
]}

Demirel, Alpay ^{[4
]}

Koroglu, Banu Kale ^{[5
]}

Colakoglu, Neriman ^{[6
]}

Kukner, Aysel ^{[7
]}

Soenmez, Tolga Taha ^{[8
]}

机构：

[1] Suleyman Demirel Univ, Dept Biophys, Fac Med, TR-32260 Isparta, Turkey

[2] Suleyman Demirel Univ, Dept Ophthalmol, Fac Med, TR-32260 Isparta, Turkey

[3] Bezmialem Vakif Univ, Fac Med, Dept Urol, Istanbul, Turkey

[4] Kariyer Eye Hosp, Dept Ophthalmol, Isparta, Turkey

[5] Suleyman Demirel Univ, Dept Internal Med, Div Endocrinol, Fac Med, TR-32260 Isparta, Turkey

[6] Firat Univ, Fac Med, Dept Histol & Embryol, TR-23169 Elazig, Turkey

[7] Abant Izzet Baysal Univ, Fac Med, Dept Histol & Embryol, Bolu, Turkey

[8] Rhein Westfal TH Aachen, Dept Oral Cranio Maxillofacial & Plast Facial Sur, Aachen, Germany

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2011年 / 29卷 / 04期

关键词：

diabetes; aged; kidney; lens; vitamin C and E; oxidative stress; hematological values; E COMBINATION PROTECTS; MODERATE EXERCISE; IMPROVES; BLOOD; SUPPLEMENTATION; SELENIUM; PRODUCT; TISSUE; DAMAGE;

D O I：

10.1002/cbf.1749

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes induces oxidative stress in aged human and rat, although daily supplementation of vitamins C and E (VCE) can be beneficial to aged diabetic rats by reducing free radical production. The aim of the present study was to evaluate whether dietary VCE supplementation relieves oxidative stress in streptozotocin (STZ)-induced diabetic in aged rats. Thirty aged rats were randomly divided into three groups. The first group was used as a control. The second group was made diabetic using a single dose of intraperitoneal STZ. VCE-supplemented feed was given to aged diabetic rats constituting the third group. On the 21st day of the experiment, blood, lens and kidney samples were taken from all animals. Glutathione peroxidase (GSH-Px) activity in lens and kidney, reduced glutathione (GSH), vitamin E and beta-carotene concentrations in kidney were lower in the diabetic group than in the control whereas plasma glucose, urea and creatinine, and kidney and lens peroxidation (LP) levels were higher in the diabetic group than in the control. However, kidney and lens LP levels, and plasma glucose, urea and creatinine values were decreased by VCE supplementation. Lens and kidney GSH-Px activity, kidney GSH, vitamin E and beta-carotene concentrations and erythrocyte counts were increased by VCE treatment. Kidney weights, vitamin A, haemoglobin, hematocrit, leukocyte and platelets values were not changed by diabetes and/or VCE supplementation. VCE ameliorated also diabetes-induced histopathological changes in kidney. In conclusion, we observed that VCE supplementation is beneficial towards kidney and lens of aged diabetic rats by modulating oxidative and antioxidant systems. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：287 / 293

页数：7

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