Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era

被引：11

作者：

Moding, Everett J. ^{[1
,2
]}

Mowery, Yvonne M. ^{[1
]}

Kirsch, David G. ^{[1
,3
]}

机构：

[1] Duke Univ, Dept Radiat Oncol, Durham, NC USA

[2] Moses Cone Mem Hosp, Dept Internal Med, Greensboro, NC USA

[3] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC USA

来源：

CANCER JOURNAL | 2016年 / 22卷 / 04期

关键词：

DNA repair; endothelial cells; hypoxia; immune therapy; radiosensitizers; stereotactic body radiation therapy; CANCER STEM-CELLS; TUMOR RESPONSE; IMMUNE-RESPONSES; LOCAL RADIATION; MOUSE MODEL; T-CELLS; RADIOTHERAPY; IMMUNOTHERAPY; INHIBITORS; RADIOBIOLOGY;

D O I：

10.1097/PPO.0000000000000203

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stereotactic body radiation therapy (SBRT) utilizing a small number of high-dose radiation therapy fractions continues to expand in clinical application. Although many approaches have been proposed to radiosensitize tumors with conventional fractionation, how these radiosensitizers will translate to SBRT remains largely unknown. Here, we review our current understanding of how SBRT eradicates tumors, including the potential contributions of endothelial cell death and immune system activation. In addition, we identify several new opportunities for radiosensitization generated by the move toward high dose per fraction radiation therapy.

引用

页码：267 / 273

页数：7

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