Solubility of acetylsalicylic acid in ethanol, acetone, propylene glycol, and 2-propanol

被引：53

作者：

Maia, Gustavo D. ^{[1
]}

Giulietti, Marco ^{[2
,3
,4
]}

机构：

[1] Univ Fed Sao Carlos, Dept Chem Engn, DEQ, UFSCar, BR-13560 Sao Carlos, SP, Brazil

[2] CTPP, Sao Carlos, SP, Brazil

[3] Technol Res Inst, IPT, Sao Carlos, SP, Brazil

[4] Univ Fed Sao Carlos, Fed Dept Chem Engn, UFSCar, DEQ, BR-13560 Sao Carlos, SP, Brazil

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2008年 / 53卷 / 01期

关键词：

D O I：

10.1021/je7005693

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

As one of the most regularly traded-in medicines in the world, acetylsalicylic acid has been scarcely researched when in solution. This study is aimed at determining the solubility of acetylsalicylic acid in ethanol, acetone, propylene glycol, and 2-propanol, in addition to comparing their solubility values with the expected from an ideal solution. The solubility of acetylsalicylic acid is highest in acetone in all studied temperature ranges until T/K = 326.3. Propylene glycol presents lower solubility data in all studied temperature ranges. The solvent that presented the lowest average percent logarithmic deviation, concerning the ideality of the system, was ethanol, and the highest value of average percent logarithmic deviation was found in propylene glycol solutions. The experimental solubility data were correlated with the Nyvlt model. We conclude that the Nyvlt model is' capable of representing properly the experimental data.

引用

页码：256 / 258

页数：3