Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Leprfa) rat

被引：23

作者：

Akimoto, Toshio ^{[1
]}

Nakama, Kazumasa ^{[2
]}

Katsuta, Yasumi ^{[3
]}

Zhang, Xue-Jun ^{[3
]}

Ohsuga, Masaru ^{[3
]}

Ishizaki, Masamichi ^{[4
]}

Sawai, Nobuhiko ^{[5
]}

Ozawa, Hitoshi ^{[5
]}

机构：

[1] Nippon Med Sch, Div Lab Anim Sci, Bunkyo Ku, Tokyo 1138602, Japan

[2] Shizuoka Lab Anim Ctr, Hamamatsu, Shizuoka 4311103, Japan

[3] Nippon Med Sch, Dept Internal Med 1, Bunkyo Ku, Tokyo 1138602, Japan

[4] Nippon Med Sch, Dept Pathol, Bunkyo Ku, Tokyo 1138602, Japan

[5] Nippon Med Sch, Dept Anat & Neurobiol, Bunkyo Ku, Tokyo 1138602, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 366卷 / 02期

关键词：

diabetes; obesity; fatty; leptin receptor; pancreatitis; congenic strain; WBN/Kob rat;

D O I：

10.1016/j.bbrc.2007.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The WBN/Kob-Lepr(fa) rat is a new congenic strain for the fa allele of the leptin receptor gene (Lepr). Homozygous (fa/fa) WBN/Kob-Lepr(fa) rats provide a model of non-insulin-dependent diabetes with obesity. Here, we describe the characteristics of this new animal model in detail. At 7 weeks of age, both male and female obese WBN/Kob rats showed inflammatory cell infiltration of the pancreas that suggested pan-pancreatitis and an abnormal OGTT. At 3 months of age, both male and female obese WBN/Kob rats developed overt diabetes mellitus associated with severe chronic pancreatitis. In contrast, lean female WBN/Kob rats do not develop pancreatitis or diabetes. In WBN/Kob rats, this mutation might promote the onset of severe pancreatitis, leading to the rapid development of diabetes mellitus. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：556 / 562

页数：7

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