SPICE macromodel of silicon-on-insulator-field-effect-transistor-based biological sensors

被引：24

作者：

Fernandes, Poornika G. ^{[1
]}

Stiegler, Harvey J. ^{[2
]}

Zhao, Mingyue ^{[1
]}

Cantley, Kurds D. ^{[1
]}

Obradovic, Borna ^{[3
]}

Chapman, Richard A. ^{[2
]}

Wen, Huang-Chun ^{[3
]}

Mahmud, Gazi ^{[2
]}

Vogel, Eric M. ^{[1
,2
,4
]}

机构：

[1] Univ Texas Dallas, Dept Elect Engn, Richardson, TX 75080 USA

[2] Univ Texas Dallas, Dept Mat Sci & Engn, Richardson, TX 75080 USA

[3] Texas Instruments Inc, Dallas, TX 75243 USA

[4] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2012年 / 161卷 / 01期

关键词：

SPICE; Model; Biosensor; FET; Sensor; SOI; pH; Macromodel; ELECTRICAL DETECTION; ISFET;

D O I：

10.1016/j.snb.2011.10.002

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A user-friendly behavioral macromodel for biological response of FET-based transistors has been developed for use with commercial SPICE versions and will enable circuit level analysis of biosensor chips. The model is based on the physically realistic representation of biological layers using an ion-permeable charged membrane model. Simulations demonstrate good agreement to experimental results. Logarithmic increments in bound membrane charge result in linear threshold voltage shifts. The model accounts for phenomena such as Debye screening of biomolecules resulting in reduced sensor response to increments in salt concentration. Additionally, the presence of site binding charge on oxide surfaces is shown to severely deteriorate sensitivity. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：163 / 170

页数：8

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