Glial Biomarkers in Human Central Nervous System Disease

被引:40
作者
Garden, Gwenn A. [1 ]
Campbell, Brian M. [2 ]
机构
[1] Univ Washington, Dept Neurol, Box 356465, Seattle, WA 98195 USA
[2] Lundbeck Res USA, Neuroinflammat DBU, Paramus, NJ USA
关键词
cerebrospinal fluid; inflammation; magnetic resonance imaging; neuroimaging; positron emission tomography; AMYOTROPHIC-LATERAL-SCLEROSIS; TRAUMATIC BRAIN-INJURY; PERIPHERAL BENZODIAZEPINE-RECEPTORS; POSITRON-EMISSION-TOMOGRAPHY; FIBRILLARY ACIDIC PROTEIN; CEREBROSPINAL-FLUID; MULTIPLE-SCLEROSIS; IN-VIVO; MICROGLIAL ACTIVATION; KYNURENINE PATHWAY;
D O I
10.1002/glia.22998
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is a growing understanding that aberrant GLIA function is an underlying factor in psychiatric and neurological disorders. As drug discovery efforts begin to focus on glia-related targets, a key gap in knowledge includes the availability of validated biomarkers to help determine which patients suffer from dysfunction of glial cells or who may best respond by targeting glia-related drug mechanisms. Biomarkers are biological variables with a significant relationship to parameters of disease states and can be used as surrogate markers of disease pathology, progression, and/or responses to drug treatment. For example, imaging studies of the CNS enable localization and characterization of anatomical lesions without the need to isolate tissue for biopsy. Many biomarkers of disease pathology in the CNS involve assays of glial cell function and/or response to injury. Each major glia subtype (oligodendroglia, astroglia and microglia) are connected to a number of important and useful biomarkers. Here, we describe current and emerging glial based biomarker approaches for acute CNS injury and the major categories of chronic nervous system dysfunction including neurodegenerative, neuropsychiatric, neoplastic, and autoimmune disorders of the CNS. These descriptions are highlighted in the context of how biomarkers are employed to better understand the role of glia in human CNS disease and in the development of novel therapeutic treatments.
引用
收藏
页码:1755 / 1771
页数:17
相关论文
共 172 条
  • [1] The Effects of Vagus Nerve Stimulation on Pro- and Anti-Inflammatory Cytokines in Children with Refractory Epilepsy: An Exploratory Study
    Aalbers, Marlien Wilhelmina
    Klinkenberg, Sylvia
    Rijkers, Kim
    Verschuure, Pauline
    Kessels, Alfons
    Aldenkamp, Albert
    Vles, Johan
    Majoie, Marian
    [J]. NEUROIMMUNOMODULATION, 2012, 19 (06) : 352 - 358
  • [2] Histone Deacetylases Enzyme, Copper, and IL-8 Levels in Patients With Alzheimer's Disease
    Alsadany, Mohamad A.
    Shehata, Hanan H.
    Mohamad, Magda I.
    Mahfouz, Riham G.
    [J]. AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, 2013, 28 (01): : 54 - 61
  • [3] ALTAR CA, 1990, EXP NEUROL, V109, P333
  • [4] [Anonymous], GERIATR GERONTOL INT
  • [5] [Anonymous], J NEUROTRAUMA
  • [6] Microglia, amyloid and dementia in Alzheimer disease - A correlative study
    Arends, YM
    Duyckaerts, C
    Rozemuller, JM
    Eikelenboom, P
    Hauw, JJ
    [J]. NEUROBIOLOGY OF AGING, 2000, 21 (01) : 39 - 47
  • [7] Myelin water weighted diffusion tensor imaging
    Avram, Alexandru V.
    Guidon, Arnaud
    Song, Allen W.
    [J]. NEUROIMAGE, 2010, 53 (01) : 132 - 138
  • [8] Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis
    Avsar, Timucin
    Korkmaz, Didem
    Tutuncu, Melih
    Demirci, N. Onat
    Saip, Sabahattin
    Kamasak, Mustafa
    Siva, Aksel
    Turanli, Eda Tahir
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (08) : 1081 - 1091
  • [9] Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury
    Banati, RB
    Cagnin, A
    Brooks, DJ
    Gunn, RN
    Myers, R
    Jones, T
    Birch, R
    Anand, P
    [J]. NEUROREPORT, 2001, 12 (16) : 3439 - 3442
  • [10] PK ('peripheral benzodiazepine') - Binding sites in the CNS indicate early and discrete brain lesions: Microautoradiographic detection of [H-3]PK11195 binding to activated microglia
    Banati, RB
    Myers, R
    Kreutzberg, GW
    [J]. JOURNAL OF NEUROCYTOLOGY, 1997, 26 (02): : 77 - 82