The bactericidal/permeability-increasing protein (BPI) in the innate defence of the lower airways

被引:14
|
作者
Holweg, Alexander [1 ]
Schnare, Markus [2 ]
Gessner, Andre [1 ]
机构
[1] Univ Klinikum Regensburg, Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany
[2] Univ Marburg, Inst Immunol, D-35032 Marburg, Germany
关键词
antimicrobial peptide; bactericidal/permeability-increasing protein (BPI); cystic fibrosis; lung innate immunity; pneumonia; GRAM-NEGATIVE BACTERIA; CYSTIC-FIBROSIS PATIENTS; LIPOPOLYSACCHARIDE-BINDING PROTEIN; AMINO-TERMINAL FRAGMENT; PSEUDOMONAS-AERUGINOSA; INDUCED EXPRESSION; HOST-DEFENSE; IN-VITRO; DISEASE; INFECTION;
D O I
10.1042/BST0391045
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The human BPI (bactericidal/permeability-increasing protein), stored in primary azurophilic granula of neutrophil granulocytes and produced by mucosal epithelia, has been known for decades to bind LPS (lipopolysaccharide) with very high affinity and to efficiently kill Gram-negative bacteria. Thus BPI potentially represents a central component of the innate immune system to directly combat microbes and modulate subsequent adaptive immune responses. Especially in the lungs, which are frequently exposed to a variety of inhaled pathogens, antimicrobial innate defence molecules such as BPI, are of exceptional relevance. In the present review, we highlight possible functions of BPI during acute pneumonia and CF (cystic fibrosis)-associated chronic infections in the lung.
引用
收藏
页码:1045 / 1050
页数:6
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