The human BPI (bactericidal/permeability-increasing protein), stored in primary azurophilic granula of neutrophil granulocytes and produced by mucosal epithelia, has been known for decades to bind LPS (lipopolysaccharide) with very high affinity and to efficiently kill Gram-negative bacteria. Thus BPI potentially represents a central component of the innate immune system to directly combat microbes and modulate subsequent adaptive immune responses. Especially in the lungs, which are frequently exposed to a variety of inhaled pathogens, antimicrobial innate defence molecules such as BPI, are of exceptional relevance. In the present review, we highlight possible functions of BPI during acute pneumonia and CF (cystic fibrosis)-associated chronic infections in the lung.
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Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Aquino-Dominguez, Alba Soledad
Romero-Tlalolini, Maria de los Angeles
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Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Consejo Nacl Humanidades Ciencias & Tecnol, Oaxaca 68120, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Romero-Tlalolini, Maria de los Angeles
Torres-Aguilar, Honorio
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Univ Autonoma Benito Juarez Oaxaca, Fac Ciencias Quim, Oaxaca 68120, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Torres-Aguilar, Honorio
Rodriguez-Alba, Juan Carlos
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Inst Nacl Neurol & Neurocirug, Unidad Neuroinmunol & Neurooncol, Mexico City 14269, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Rodriguez-Alba, Juan Carlos
Martinez-Martinez, Lucia Lourdes
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Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Martinez-Martinez, Lucia Lourdes
Sanchez-Pena, Francisco Javier
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Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Sanchez-Pena, Francisco Javier
Hernandez-Huerta, Maria Teresa
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Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Consejo Nacl Humanidades Ciencias & Tecnol, Oaxaca 68120, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Hernandez-Huerta, Maria Teresa
Elizarraras-Rivas, Jesus
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Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Inst Mexicano Seguro Social IMSS, Coordinac Invest Salud, Oaxaca 68000, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Elizarraras-Rivas, Jesus
Tapia-Pastrana, Gabriela
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Hosp Alta Especialidad Oaxaca, Inst Mexicano Seguro Social Bienestar IMSS BIENEST, Serv Salud, San Bartolo Coyotepec 71294, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Tapia-Pastrana, Gabriela
Gomez-Lopez, Melisa
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Hosp Gen Aurelio Valdivieso MD, Secretaria Salud SS, Oaxaca 68000, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Gomez-Lopez, Melisa
Cruz-Martinez, Elsa
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Hosp Gen Aurelio Valdivieso MD, Secretaria Salud SS, Oaxaca 68000, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Cruz-Martinez, Elsa
Hernandez-Corrales, Uriel Eleazar
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Hosp Comunitario Nejapa De Madero, Nejapa De Madero 70531, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico
Hernandez-Corrales, Uriel Eleazar
Aguilar-Ruiz, Sergio Roberto
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Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, MexicoUniv Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68120, Oaxaca, Mexico