Synthesis and evaluation of 1H-pyrazolo[3,4-b]quinoxalines and 1-aryl-3-quinoxalinyl-1,2,4-triazole as antibacterial agent

被引：22

作者：

Kim, HS ^{[1
]}

Chung, JY ^{[1
]}

Kim, EK ^{[1
]}

Park, YT ^{[1
]}

Hong, YS ^{[1
]}

Lee, MK ^{[1
]}

Kurasawa, Y ^{[1
]}

Takada, A ^{[1
]}

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 06期

关键词：

D O I：

10.1002/jhet.5570330649

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 1H-pyrazolo[3,4-b]quinoxalines (flavazoles) 14, 15 and 1-aryl-3-quinoxalinyl-1,2,4-triazole 17 were synthesized from the ester 11 via various hydrazones 12, 13 and 16. In the antibacterial screening test of compounds 12-17, compound 14 showed a relatively high antibacterial activity, wherein the MIC value was 25 mu g/ml against Bacillus licheniformis KTCC 21425 and Cellulomonas sp. and 50 mu g/ml against Salmonella typhimurium KCTC 1925 and Flavobacterium devolans.

引用

页码：1855 / 1858

页数：4

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