Synthesis and evaluation of 1H-pyrazolo[3,4-b]quinoxalines and 1-aryl-3-quinoxalinyl-1,2,4-triazole as antibacterial agent

被引：22

作者：

Kim, HS ^{[1
]}

Chung, JY ^{[1
]}

Kim, EK ^{[1
]}

Park, YT ^{[1
]}

Hong, YS ^{[1
]}

Lee, MK ^{[1
]}

Kurasawa, Y ^{[1
]}

Takada, A ^{[1
]}

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 06期

关键词：

D O I：

10.1002/jhet.5570330649

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 1H-pyrazolo[3,4-b]quinoxalines (flavazoles) 14, 15 and 1-aryl-3-quinoxalinyl-1,2,4-triazole 17 were synthesized from the ester 11 via various hydrazones 12, 13 and 16. In the antibacterial screening test of compounds 12-17, compound 14 showed a relatively high antibacterial activity, wherein the MIC value was 25 mu g/ml against Bacillus licheniformis KTCC 21425 and Cellulomonas sp. and 50 mu g/ml against Salmonella typhimurium KCTC 1925 and Flavobacterium devolans.

引用

页码：1855 / 1858

页数：4

共 50 条

[1] SULFONATION OF 1H-PYRAZOLO(3,4-B)QUINOXALINES
KOHLSTOC.B
HENSEKE, G
ZEITSCHRIFT FUR CHEMIE, 1973, 13 (03): : 100 - 101
[2] A SELECTIVE SYNTHESIS OF 1-ARYL-3-QUINOXALINYL-1,2,4-TRIAZOLE AND FURO[2,3-B]QUINOXALINE
KIM, HS
KURASAWA, Y
TAKADA, A
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (04) : 1129 - 1133
[3] A CONVENIENT SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 1-ARYL-1H-PYRAZOLO[3,4-B]QUINOXALINES AND 1-ARYL-3-HETEROARYL-1H-PYRAZOLO[3,4-B]QUINOXALINES
KURASAWA, Y
MURAMATSU, M
YAMAZAKI, K
TAJIMA, S
OKAMOTO, Y
TAKADA, A
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (05) : 1379 - 1382
[4] Synthesis and biological activity of new 1H-pyrazolo[3,4-b]quinoxalines (flavazoles)
Shawali, AS
Zayed, MM
Farghaly, TA
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 42 (02) : 185 - 189
[5] SYNTHESIS OF 1H-PYRAZOLO[3,4-B]PYRIDINE
HATT, TLP
VASS, JDR
CHEMICAL COMMUNICATIONS, 1966, (10) : 293 - &
[6] Quinoxalines X.: A new and convenient synthesis of 1H-pyrazolo[3,4-b]quinoxalines (flavazoles)
Sarodnick, G
Linker, T
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 38 (04) : 829 - 836
[7] A FACILE SYNTHESIS OF NOVEL 1-ARYL-1H-PYRAZOLO[3,4-B]QUINOXALINES
KURASAWA, Y
YAMAZAKI, K
TAJIMA, S
OKAMOTO, Y
TAKADA, A
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (01) : 281 - 282
[8] Photophysical properties of derivatives of 1H-pyrazolo[3,4-b]quinoline and 1H-pyrazolo[3,4-b]quinoxaline
Mac, M.
Uchacz, T.
Andrzejak, M.
Dane, A.
Szlachcic, P.
Nowak, P.
POLISH JOURNAL OF CHEMISTRY, 2007, 81 (04) : 557 - 572
[9] PHENYLATION AND DEPENYLATION REACTIONS - FORMATION OF 1H-PYRAZOLO[3,4-B]QUINOXALINES
PILLAI, PM
RAMABHADRAN, P
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1986, 25 (09): : 901 - 904
[10] 1H-PYRAZOLO[3,4-B] PYRIDINES
HOHN, H
JANSSEN, W
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1972, 9 (02) : 235 - &

← 1 2 3 4 5 →