Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problems

被引：101

作者：

Gardiner, Bradley J. ^{[1
]}

Stewardson, Andrew J. ^{[1
]}

Abbott, Iain J. ^{[1
,2
]}

Peleg, Anton Y. ^{[1
,3
]}

机构：

[1] Monash Univ, Alfred Hlth & Cent Clin Sch, Dept Infect Dis, Melbourne, Vic, Australia

[2] Erasmus MC, Dept Med Microbiol & Infect Dis, Res & Dev Unit, Rotterdam, Netherlands

[3] Monash Univ, Biomed Discovery Inst, Dept Microbiol, Melbourne, Vic, Australia

来源：

AUSTRALIAN PRESCRIBER | 2019年 / 42卷 / 01期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

antibiotic resistance; fosfomycin; nitrofurantoin; urinary tract infection; SINGLE-DOSE FOSFOMYCIN; PROGRAM ANNUAL-REPORT; ESCHERICHIA-COLI; ANTIMICROBIAL RESISTANCE; CEFTAZIDIME-AVIBACTAM; ANTIBIOTIC-RESISTANCE; DISEASES-SOCIETY; ORAL FOSFOMYCIN; UNITED-STATES; ENTEROBACTERIACEAE;

D O I：

10.18773/austprescr.2019.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Uncomplicated urinary tract infection is one of the most common indications for antibiotic use in the community. However, the Gram-negative organisms that can cause the infection are becoming more resistant to antibiotics. Many multidrug resistant organisms retain susceptibility to two old antibiotics, nitrofurantoin and fosfomycin. Advantages over newer drugs include their high urinary concentrations and minimal toxicity. Fosfomycin is a potential treatment option for patients with uncomplicated urinary tract infection due to resistant organisms. Nitrofurantoin may be more effective and can be used for urinary infections in pregnant women.

引用

页码：14 / 19

页数：6

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