RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress

被引：17

作者：

Cho, Er-Chieh ^{[1
,2
]}

Kuo, Mei-Ling ^{[3
]}

Cheng, Jia-hui ^{[1
]}

Cheng, Yu-Chi ^{[4
]}

Hsieh, Yi-Chen ^{[5
]}

Liu, Yun-Ru ^{[6
]}

Hsieh, Rong-Hong ^{[4
]}

Yen, Yun ^{[7
]}

机构：

[1] Taipei Med Univ, Coll Pharm, Sch Pharm, Dept Clin Pharm, Taipei 110, Taiwan

[2] Taipei Med Univ, Master Program Clin Pharmacogen & Pharmacoprote, Sch Pharm, Taipei 110, Taiwan

[3] City Hope Natl Med Ctr, Beckman Res Inst, Dept Mol Pharmacol, Duarte, CA 91010 USA

[4] Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Nutr & Hlth Sci, Taipei 110, Taiwan

[5] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Neural Regenerat Med, Taipei 110, Taiwan

[6] Taipei Med Univ, Joint Biobank, Off Human Res, Taipei 110, Taiwan

[7] Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery, Taipei 110, Taiwan

来源：

MEDIATORS OF INFLAMMATION | 2015年 / 2015卷

关键词：

NF-KAPPA-B; HUMAN RIBONUCLEOTIDE REDUCTASE; CYTOCHROME-C-OXIDASE; SMALL-SUBUNIT P53R2; HEPATOCELLULAR-CARCINOMA; MYELOID TRANSFORMATION; POTENTIAL TARGET; REDOX PROPERTY; CANCER-CELLS; DNA;

D O I：

10.1155/2015/287345

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularly under oxidative stress, remains largely unknown. In this study, we investigated the role of RRM2B underoxidative stress-induced DNA damage and further examined the regulation of mitochondrial and inflammatory genes by RRM2B. Our study is the first to report the critical role of RRM2B in mitochondrial homeostasis and the inflammation signaling pathway in a p53-independent manner. Furthermore, our study provides novel insights into the role of the RR in inflammatory diseases.

引用

页数：8

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