Initiation of protein synthesis: a target for antimicrobials

被引:9
作者
Brandi, Letizia [2 ]
Fabbretti, Attilio
Pon, Cynthia L. [3 ]
Dahlberg, Albert E. [1 ]
Gualerzi, Claudio O. [1 ]
机构
[1] Brown Univ, Dept Biochem Mol Biol & Cell Biol, Providence, RI 02912 USA
[2] Insubrias BioPk, FIIRV, Gerenzano, VA, Italy
[3] Univ Camerino, Dept Biol MCA, I-62032 Camerino, MC, Italy
关键词
edeine; fMet-tRNA; GE81112; kasugamycin; mRNA; orthosomycin; oxazolidinones; pactamycin; thiostrepton; trimethoprim;
D O I
10.1517/14728222.12.5.519
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Translation initiation is a basic and universal biological process that employs significantly different components and displays substantially different mechanisms in bacterial, archaeal and eukaryotic cells. A large amount of detailed mechanistic and structural information on the bacterial translation initiation apparatus has been uncovered in recent years. Objective: to understand which translation initiation steps could represent a novel or underexploited target for the discovery of new and specific antibacterial drugs. Methods: Brief descriptions of the properties and mechanism of action of the major antibiotics that have a documented direct inhibitory effect on bacterial translation initiation are presented. Results/conclusions: Considerations and predictions concerning a future scenario for research and identification of bacterial translation initiation inhibitors are presented.
引用
收藏
页码:519 / 534
页数:16
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