Recent Advances in Cardiac Tissue Engineering for the Management of Myocardium Infarction

被引：29

作者：

Sharma, Vineeta ^{[1
]}

Dash, Sanat Kumar ^{[2
]}

Govarthanan, Kavitha ^{[1
]}

Gahtori, Rekha ^{[3
]}

Negi, Nidhi ^{[4
]}

Barani, Mahmood ^{[5
]}

Tomar, Richa ^{[6
]}

Chakraborty, Sudip ^{[7
]}

Mathapati, Santosh ^{[8
]}

Bishi, Dillip Kumar ^{[9
]}

Negi, Poonam ^{[10
]}

Dua, Kamal ^{[11
,12
]}

Singh, Sachin Kumar ^{[13
]}

Gundamaraju, Rohit ^{[14
]}

Dey, Abhijit ^{[15
]}

Ruokolainen, Janne ^{[16
]}

Thakur, Vijay Kumar ^{[17
,18
]}

Kesari, Kavindra Kumar ^{[16
,19
]}

Jha, Niraj Kumar ^{[20
]}

Gupta, Piyush Kumar ^{[21
]}

Ojha, Shreesh ^{[22
]}

机构：

[1] Bhupat & Jyoti Mehta Sch Biosci, Indian Inst Technol Madras, Dept Biotechnol, Stem Cell & Mol Biol Lab, Chennai 600036, Tamil Nadu, India

[2] Indian Inst Technol Madras, Dept Mech Engn, Heat Transfer & Thermal Power Lab, Chennai 600036, Tamil Nadu, India

[3] Kumaun Univ, Dept Biotechnol, Sir JC Bose Tech Campus, Naini Tal 263136, India

[4] Kumaun Univ, Dept Chem, DSB Campus, Naini Tal 263001, India

[5] Kerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran

[6] Sharda Univ, Sch Basic Sci & Res, Dept Chem & Biochem, Knowledge Pk 3, Greater Noida 201310, India

[7] Univ New South Wales, Sch Chem, Kensington, NSW 2033, Australia

[8] NCR Biotech Sci Cluster, Translat Hlth Sci & Technol Inst, 3rd Milestone, Faridabad 121001, India

[9] Rama Devi Womens Univ, Dept Biotechnol, Bhubaneswar 751022, India

[10] Shoolini Univ Biotechnol & Management Sci, Sch Pharmaceut Sci, Solan 173212, India

[11] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia

[12] Univ Technol Sydney, Australian Res Ctr Complementary & Integrat Med, Fac Hlth, Sydney, NSW 2007, Australia

[13] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144001, India

[14] Univ Tasmania, Sch Hlth Sci, ER Stress & Mucosal Immunol Lab, Launceston, Tas 7248, Australia

[15] Presidency Univ, Dept Life Sci, Coll St, Kolkata 700073, India

[16] Aalto Univ, Sch Sci, Dept Appl Phys, Espoo 00076, Finland

[17] Scotlands Rural Coll SRUC, Biorefining & Adv Mat Res Ctr, Kings Bldg, Edinburgh EH9 3JG, Midlothian, Scotland

[18] Univ Petr & Energy Studies UPES, Sch Engn, Dehra Dun 248007, Uttarakhand, India

[19] Aalto Univ, Sch Chem Engn, Dept Bioprod & Biosyst, Espoo 00076, Finland

[20] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Knowledge Pk 3, Greater Noida 201310, India

[21] Sharda Univ, Sch Basic Sci & Res, Dept Life Sci, Knowledge Pk 3, Greater Noida 201310, India

[22] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, POB 17666, Al Ain, U Arab Emirates

来源：

CELLS | 2021年 / 10卷 / 10期

关键词：

myocardial infarction; stem cells; regeneration; biomaterial; cardiomyocytes; tissue engineering; ON-A-CHIP; CELL-DERIVED CARDIOMYOCYTES; EMBRYONIC STEM-CELLS; EXTRACELLULAR-MATRIX; HEART REGENERATION; IN-VITRO; MICROFLUIDIC DEVICE; BIOMEDICAL APPLICATIONS; INJECTABLE HYDROGELS; SKELETAL MYOBLASTS;

D O I：

10.3390/cells10102538

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Myocardium Infarction (MI) is one of the foremost cardiovascular diseases (CVDs) causing death worldwide, and its case numbers are expected to continuously increase in the coming years. Pharmacological interventions have not been at the forefront in ameliorating MI-related morbidity and mortality. Stem cell-based tissue engineering approaches have been extensively explored for their regenerative potential in the infarcted myocardium. Recent studies on microfluidic devices employing stem cells under laboratory set-up have revealed meticulous events pertaining to the pathophysiology of MI occurring at the infarcted site. This discovery also underpins the appropriate conditions in the niche for differentiating stem cells into mature cardiomyocyte-like cells and leads to engineering of the scaffold via mimicking of native cardiac physiological conditions. However, the mode of stem cell-loaded engineered scaffolds delivered to the site of infarction is still a challenging mission, and yet to be translated to the clinical setting. In this review, we have elucidated the various strategies developed using a hydrogel-based system both as encapsulated stem cells and as biocompatible patches loaded with cells and applied at the site of infarction.

引用

页数：35

共 221 条

[1] Engineering anisotropic cardiac monolayers on microelectrode arrays for non-invasive analyses of electrophysiological properties [J].