A new route to 2-spiropiperidines

被引：22

作者：

Ciblat, S ^{[1
]}

Canet, JL ^{[1
]}

Troin, Y ^{[1
]}

机构：

[1] Univ Blaise Pascal, Ecole Natl Super Chim Clemont Ferrand, Lab Chim Heterocylces & Glucides, F-63174 Aubiere, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(01)00881-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular Mannich reaction, involving cyclanones together with a ketoprotected aminobutanone in the presence of a Lewis acid, is employed to prepare rapidly 2,2 ' -spiropiperidine skeletons. Phis approach is validated through a concise and efficient synthesis of spiro [piperidine-2,2 ' -adamantane] 4, an antiviral agent. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：4815 / 4817

页数：3

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