Sesquiterpenoids from Inula racemosa Hook. f. Inhibit Nitric Oxide Production

被引：29

作者：

Zhang, Shou-De ^{[2
]}

Qin, Jiang-Jiang ^{[2
]}

Jin, Hui-Zi ^{[2
]}

Yin, Yin-Hua ^{[1
]}

Li, Hong-Lin ^{[3
]}

Yang, Xian-Wen ^{[4
]}

Li, Xia ^{[1
]}

Shan, Lei ^{[1
]}

Zhang, Wei-Dong ^{[1
,2
]}

机构：

[1] Second Mil Med Univ, Dept Nat Product Chem, Sch Pharm, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China

[3] E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

[4] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 02期

关键词：

Inula racemosa Hook. f; Compositae; sesquiterpenes; density functional theory; nitric oxide; ELECTRONIC CIRCULAR-DICHROISM; LACTONES; BRITANNICA; EUDESMANOLIDE; CONSTITUENTS; GROWTH;

D O I：

10.1055/s-0031-1280294

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC50 values of 7.39 +/- 0.36, 6.35 +/- 0.26, and 5.39 +/- 0.18 mu M, respectively.

引用

页码：166 / 171

页数：6

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