Triterpenoids with neurotrophic activity from Ganoderma lucidum

被引：55

作者：

Zhang, Xiao-Qi ^{[1
,2
]}

Ip, Fanny C. F. ^{[3
]}

Zhang, Dong-Mei ^{[2
]}

Chen, Li-Xin ^{[2
]}

Zhang, Wei ^{[2
]}

Li, Yao-Lan ^{[1
,2
]}

Ip, Nancy Y. ^{[3
]}

Ye, Wen-Cai ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[3] Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2011年 / 25卷 / 17期

关键词：

Ganoderma lucidum; triterpenoid; 4,4,14 alpha-trimethyl-5 alpha-chol-7,9(11)-dien-3-oxo-24-oic acid; neurotrophic activity; FR KARST; CONSTITUENTS; PROLIFERATION; SURVIVAL;

D O I：

10.1080/14786419.2010.496367

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new triterpenoid, 4,4,14 alpha-trimethyl-5 alpha-chol-7,9(11)-dien-3-oxo-24-oic acid (1), together with seven known triterpenoids, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by extensive spectroscopic analyses. Bioassay results revealed that compounds 1 and methyl ganoderic acid B (5) had nerve growth factor-like neuronal survival-promoting effects, whereas compounds 1, and 4-7 showed brain-derived neurotrophic factor-like neuronal survival-promoting activities.

引用

页码：1607 / 1613

页数：7

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