Synthesis of novel 15-membered macrolide derivatives

被引：4

作者：

Xian, Rui Qing ^{[1
]}

Ma, Shu Tao ^{[1
]}

Jiao, Bo ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharm, Jinan 250012, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2008年 / 19卷 / 04期

基金：

中国国家自然科学基金;

关键词：

macrolide; azithromycin derivatives; synthesis; 4 ''-carbamate derivatives;

D O I：

10.1016/j.cclet.2008.01.040

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to develop new antibiotics effective against resistant bacteria, a series of novel 15-membered macrolide derivatives were designed and synthesized by the modification of hydroxyl groups at C-11, C-12 and C-4 '' positions. Their structures were confirmed by MS, IR, H-1 NMR or C-13 NMR. (c) 2008 Shu Tho Ma. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：409 / 411

页数：3

共 8 条

[1]

ANDERSON M, 1999, 38 INT C ANT AG CHEM

[2] Superiority of 11,12 carbonate macrolide antibiotics as inhibitors of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells [J].

Champney, WS ;

Tober, CL .

CURRENT MICROBIOLOGY, 1999, 38 (06) :342-348

[3] NEW MACROLIDES ACTIVE AGAINST STREPTOCOCCUS-PYOGENES WITH INDUCIBLE OR CONSTITUTIVE TYPE OF MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN-B RESISTANCE [J].

FERNANDES, PB ;

BAKER, WR ;

FREIBERG, LA ;

HARDY, DJ ;

MCDONALD, EJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (01) :78-81

[4] Implications of antimicrobial resistance in the empirical treatment of community-acquired respiratory tract infections: the case of macrolides [J].

Lonks, JR ;

Garau, J ;

Medeiros, AA .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 50 :87-91

[5]

MASAMUNE H, Patent No. 6025350

[6]

SU WG, 1998, 38 INT C ANT AG CHEM

[7] Recent developments on ketolides and macrolides [J].

Wu, YJ ;

Su, WG .

CURRENT MEDICINAL CHEMISTRY, 2001, 8 (14) :1727-1758

[8] Review of macrolides and ketolides - Focus on respiratory tract infections [J].

Zhanel, GG ;

Dueck, M ;

Hoban, DJ ;

Vercaigne, LM ;

Embil, JM ;

Gin, AS ;

Karlowsky, JA .

DRUGS, 2001, 61 (04) :443-498

← 1 →