Predictive validity of conversion from the clinical high risk syndrome to frank psychosis

被引：24

作者：

Sykes, Laura A. Yoviene ^{[1
,2
]}

Ferrara, Maria ^{[1
,2
,3
]}

Addington, Jean ^{[6
]}

Bearden, Carrie E. ^{[8
,9
,10
]}

Cadenhead, Kristin S. ^{[11
]}

Cannon, Tyrone D. ^{[1
,12
]}

Cornblatt, Barbara A. ^{[13
]}

Perkins, Diana O. ^{[7
]}

Mathalon, Daniel H. ^{[15
]}

Seidman, Larry J. ^{[14
]}

Tsuang, Ming T. ^{[11
]}

Walker, Elaine F. ^{[4
,5
]}

McGlashan, Thomas H. ^{[1
,2
]}

Woodberry, Kristen A. ^{[14
,16
]}

Powers, Albert R., III ^{[1
,2
]}

Ponce, Allison N. ^{[1
,2
]}

Cahill, John D. ^{[1
,2
]}

Pollard, Jessica M. ^{[1
,2
]}

Srihari, Vinod H. ^{[1
,2
]}

Woods, Scott W. ^{[1
,2
]}

机构：

[1] Yale Univ, Dept Psychiat, New Haven, CT 06519 USA

[2] Yale Univ, Connecticut Mental Hlth Ctr, New Haven, CT 06519 USA

[3] AUSL Modena, Dipartimento Salute Mentale & Dipendenze Patol, Modena, Italy

[4] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[5] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA

[6] Univ Calgary, Dept Psychiat, Calgary, AB, Canada

[7] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA

[8] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA

[9] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA

[10] Univ Calif Los Angeles, Dept Biobehav Sci, Los Angeles, CA USA

[11] Univ Calif San Diego, Dept Psychiat, San Diego, CA USA

[12] Yale Univ, Dept Psychol, New Haven, CT 06519 USA

[13] Zucker Hillside Hosp, Dept Psychiat, Long Isl City, NY USA

[14] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[15] UCSF, Dept Psychiat, San Francisco, CA USA

[16] Maine Med Ctr, Ctr Psychiat Res, Portland, ME 04102 USA

来源：

SCHIZOPHRENIA RESEARCH | 2020年 / 216卷

关键词：

SIPS; Transition; Predictive validity; ULTRA-HIGH-RISK; AT-RISK; DIAGNOSTIC STABILITY; FUNCTIONAL OUTCOMES; EARLY INTERVENTION; MATTER VOLUME; MENTAL STATE; FOLLOW-UP; SCHIZOPHRENIA; 1ST-EPISODE;

D O I：

10.1016/j.schres.2019.12.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Although the clinical high risk for psychosis (CHR) paradigm has become well-established over the past two decades, one key component has received surprisingly little investigative attention: the predictive validity of the criteria for conversion or transition to frank psychosis. The current study evaluates the predictive validity of the transition to psychosis as measured by the Structured Interview for Psychosis-Risk Syndromes (SIPS) in CHR individuals. Participants included 33 SIPS converters and 399 CHR non-converters both from the North American Prodromal Longitudinal Study (NAPLS-2), as well as a sample of 67 separately ascertained first-episode psychosis (FEP) patients from the STEP program. Comparisons were made at baseline and one-year follow-up on demographic, diagnostic stability (SCID), and available measurement domains relating to severity of illness (psychotropic medication, psychosocial treatment, and resource utilization). Principal findings are: 1) a large majority of cases in both SIPS converters (n = 27/33, 81.8%) and FEP (n = 57/67, 85.1%) samples met criteria for continued psychosis at one-year follow-up; 2) follow-up prescription rates for current antipsychotic medication were higher in SIPS converters (n = 17/32. 53.1%) compared to SIPS non-converters (n = 81/397, 20.4%), and similar as compared to FEP cases (n = 39/65, 60%); and 3) at follow-up, SIPS converters had higher rates of resource utilization (psychiatric hospitalizations, day hospital admissions, and ER visits) than SIPS non-converters and were similar to FEP in most categories. The results suggest that the SIPS definition of psychosis onset carries substantial predictive validity. Limitations and future directions are discussed. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：184 / 191

页数：8