Autologous or allogeneic hematopoietic cell transplantation for relapsed or refractory PTCL-NOS or AITL

被引：18

作者：

Kameda, Kazuaki ^{[1
]}

Kako, Shinichi ^{[1
]}

Kim, Sung-Won ^{[2
]}

Usui, Yoshiaki ^{[3
]}

Kato, Koji ^{[4
]}

Fukuda, Takahiro ^{[2
]}

Uchida, Naoyuki ^{[5
]}

Kobayashi, Hikaru ^{[6
]}

Wakayama, Toshio ^{[7
]}

Sakaida, Emiko ^{[8
]}

Yano, Shingo ^{[9
]}

Imada, Kazunori ^{[10
]}

Nara, Miho ^{[11
]}

Ikeda, Takashi ^{[12
]}

Fuchida, Shin-Ichi ^{[13
]}

Ishikawa, Jun ^{[14
]}

Sugahara, Hiroyuki ^{[15
]}

Kanda, Junya ^{[16
]}

Kimura, Takafumi ^{[17
]}

Ichinohe, Tatsuo ^{[18
]}

Atsuta, Yoshiko ^{[19
,20
]}

Kondo, Eisei ^{[21
]}

机构：

[1] Jichi Med Univ, Div Hematol, Saitama Med Ctr, Saitama, Japan

[2] Natl Canc Ctr, Dept Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[3] Aichi Canc Ctr, Dept Prevent Med, Div Canc Informat & Control, Res Inst, Nagoya, Aichi, Japan

[4] Kyushu Univ Hosp, Dept Hematol Oncol & Cardiovasc Med, Fukuoka, Japan

[5] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Hematol, Tokyo, Japan

[6] Nagano Red Cross Hosp, Dept Hematol, Nagano, Japan

[7] Shimane Prefectural Cent Hosp, Dept Hematol & Oncol, Izumo, Shimane, Japan

[8] Chiba Univ Hosp, Dept Hematol, Chiba, Japan

[9] Jikei Univ, Div Clin Oncol & Hematol, Sch Med, Tokyo, Japan

[10] Japanese Red Cross Osaka Hosp, Dept Hematol, Osaka, Japan

[11] Akita Univ Hosp, Div Hematol Nephrol & Rheumatol, Akita, Japan

[12] Shizuoka Canc Ctr, Div Hematol & Stem Cell Transplantat, Shizuoka, Japan

[13] Japan Community Hlth Care Org Kyoto Kuramaguchi M, Dept Hematol, Kyoto, Japan

[14] Osaka Int Canc Inst, Dept Hematol, Osaka, Japan

[15] Sumitomo Hosp, Dept Hematol, Osaka, Japan

[16] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

[17] Japanese Red Cross Kinki Block Blood Ctr, Preparat Dept, Osaka, Japan

[18] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, Hiroshima, Japan

[19] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

[20] Aichi Med Univ, Dept Registry Sci Transplant & Cellular Therapy, Sch Med, Nagakute, Aichi, Japan

[21] Kawasaki Med Sch, Dept Hematol, Kurashiki, Okayama, Japan

来源：

LEUKEMIA | 2022年 / 36卷 / 05期

基金：

日本学术振兴会;

关键词：

PERIPHERAL T-CELL; INTENSITY CONDITIONING REGIMEN; LONG-TERM REMISSIONS; RESPONSE CRITERIA; CHRONIC GRAFT; LYMPHOMA; SURVIVAL; MANAGEMENT; DIAGNOSIS; WORKSHOP;

D O I：

10.1038/s41375-022-01545-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fit patients with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL) in relapsed or refractory (R/R) disease status often receive salvage chemotherapy followed by autologous hematopoietic stem cell transplantation (autoHCT) or allogeneic HCT (alloHCT). However, there is no consensus on the type of HCT that should be applied for such patients. Herein, we retrospectively evaluated the survival outcome of 760 adult R/R PTCL-NOS or AITL patients who underwent the first HCT. Among them, 318 relapsed after first remission (REL) and 442 were refractory to the primary therapy (PIF). The 4-year overall survival (OS) of autoHCT and alloHCT was 50 and 50% for REL patients, and 52 and 49% for PIF patients, respectively. In the multivariable analysis, alloHCT tended to be associated with better progression-free survival (PFS) in REL (hazard ratio [HR] 0.74; 95% confidence interval [CI]: 0.53-1.03), and significantly better PFS in PIF (HR 0.64; 95% CI: 0.46-0.88) compared with autoHCT. The subgroup analysis with propensity-score matching showed that alloHCT was associated with better OS for REL-sensitive and PIF-nonremission disease. This study suggested that the advantage of alloHCT for R/R PTCL-NOS or AITL is different, depending on the disease status at HCT.

引用

页码：1361 / 1370

页数：10

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