Innovative Cosmeceuticals: Sirtuin Activators and Anti-Glycation Compounds

被引：14

作者：

Farris, Patricia K. ^{[1
]}

机构：

[1] Tulane Univ, Sch Med, New Orleans, LA 70112 USA

来源：

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY | 2011年 / 30卷 / 03期

关键词：

glycation; photoaging; elastin; resveratrol; biopeptides; collagen; SMALL-MOLECULE ACTIVATORS; CALORIE RESTRICTION; OXIDATIVE STRESS; RESVERATROL; PRODUCT; ANTIOXIDANTS; METABOLISM; APOPTOSIS; PATHWAYS; INSIGHTS;

D O I：

10.1016/j.sder.2011.05.004

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of elasticity. The science behind skin aging has exploded in the past decade. Skin aging has now been defined on both a cellular and molecular level. The study of genomics in aging skin provides us with potential targets as points for intervention. In this regard, the science behind skin aging becomes a platform for the development of new anti-aging strategies and products. In this paper two new and emerging approaches to treat aging skin will be discussed. Sirtuin activating and antiglycation products are already being marketed by cosmetic and pharmaceutical companies. These anti-aging approaches are backed by basic science research and the ingredients used are supported by proof of concept studies although clinical trials are often lacking. It is this bench to beauty counter approach to cosmeceuticals that remains an industry standard today. Semin Cutan Med Surg 30:163-166 (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：163 / 166

页数：4

共 53 条

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