Smart Chemical Engineering-Based Lightweight and Miniaturized Attachable Systems for Advanced Drug Delivery and Diagnostics

被引：22
作者：
Chen, Wei [1 ,2 ]
Wang, Zheng [3 ,4 ]
Wang, Lin [4 ,5 ]
Chen, Xiaoyuan [6 ,7 ,8 ,9 ,10 ,11 ]
机构：
[1] Huazhong Univ Sci & Technol, Dept Pharmacol, Sch Basic Med, Tongji Med Coll, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Hubei Key Lab Drug Target Res & Pharmacodynam Eva, Wuhan 430030, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Gastrointestinal Surg, Union Hosp, Wuhan 430022, Peoples R China
[4] Huazhong Univ Sci & Technol, Res Ctr Tissue Engn & Regenerat Med, Union Hosp, Wuhan 430022, Peoples R China
[5] Huazhong Univ Sci & Technol, Dept Clin Lab, Union Hosp, Wuhan 430022, Peoples R China
[6] Natl Univ Singapore, Dept Diagnost Radiol, Yong Loo Lin Sch Med, Singapore 117597, Singapore
[7] Natl Univ Singapore, Dept Surg, Yong Loo Lin Sch Med, Singapore 117597, Singapore
[8] Natl Univ Singapore, Dept Chem & Biomol Engn, Fac Engn, Singapore 117597, Singapore
[9] Natl Univ Singapore, Dept Biomed Engn, Fac Engn, Singapore 117597, Singapore
[10] Natl Univ Singapore, Clin Imaging Res Ctr, Ctr Translat Med, Yong Loo Lin Sch Med, Singapore 117597, Singapore
[11] Natl Univ Singapore, Nanomed Translat Res Program, NUS Ctr Nanomed, Yong Loo Lin Sch Med, Singapore 117597, Singapore
来源：
ADVANCED MATERIALS | 2022年 / 34卷 / 06期
基金：
中国国家自然科学基金;
关键词：
attachable systems; biochemical functionalization; bioinspiration; lightweight; miniaturization; structural engineering; MOUTHGUARD BIOSENSOR; EPIDERMAL ELECTRONICS; WEARABLE DEVICES; STRAIN SENSOR; MICRONEEDLE; POWER; GLUCOSE; TRANSPARENT; PENETRATION; ADHESIVE;
D O I：
10.1002/adma.202106701
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Smart attachable systems have attracted much attention owing to their capabilities in terms of body performance evaluation, disease diagnostics, and drug delivery. Recent advances in chemical and engineering techniques provide many opportunities to improve device fabrication and applications owing to the advantages of being lightweight and easy to control as well as their battery absence and functional diversity. This review highlights the latest developments in the field of chemical engineering-based lightweight and miniaturized attachable systems, which are mainly inspired by the natural world. Their applications for real-time monitoring, point-of-care sampling, biomarker detection, and controlled release are discussed thoroughly with respect to specific products/prototypes. The perspectives of the field, including persistence guarantee, burden reduction, and personality improvement, are also discussed. It is believed that chemical engineering-based lightweight and miniaturized attachable systems have good potential in both clinical and industrial fields, indicating a large potential to improve human lives in the near future.
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页数：23
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