Novel synthesis naringenin-benzyl piperazine derivatives prevent glioblastoma invasion by inhibiting the hypoxia-induced IL6/JAK2/STAT3 axis and activating caspase-dependent apoptosis

被引:7
作者
Zaim, Omer [1 ]
Doganlar, Oguzhan [2 ]
Doganlar, Zeynep Banu [2 ]
Ozcan, Hafize [1 ]
Zreigh, Mohamed M. [3 ]
Kurtdere, Kardelen [2 ]
机构
[1] Trakya Univ, Dept Chem, TR-22030 Edirne, Turkey
[2] Trakya Univ, Fac Med, Dept Med Biol, TR-22030 Edirne, Turkey
[3] Zawia Univ, Fac Sci, Dept Chem, Zawia, Libya
关键词
BIOLOGICAL EVALUATION; POOR-PROGNOSIS; CELLS; ANTIOXIDANT; EXPRESSION; FLAVONOIDS; MECHANISM; LINES; TOOL;
D O I
10.1016/j.bioorg.2022.106209
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页数:11
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共 73 条
  • [41] Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis
    Migliore, Marco
    Pontis, Silvia
    de Arriba, Angel Luis Fuentes
    Realini, Natalia
    Torrente, Esther
    Armirotti, Andrea
    Romeo, Elisa
    Di Martino, Simona
    Russo, Debora
    Pizzirani, Daniela
    Summa, Maria
    Lanfranco, Massimiliano
    Ottonello, Giuliana
    Busquet, Perrine
    Jung, Kwang-Mook
    Garcia-Guzman, Miguel
    Heim, Roger
    Scarpelli, Rita
    Piomelli, Daniele
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (37) : 11193 - 11197
  • [42] Polyphenol pattern and antioxidant activity of different tomato lines and cultivars
    Minoggio, M
    Bramati, L
    Simonetti, P
    Gardana, C
    Iemoli, L
    Santangelo, E
    Mauri, PL
    Spigno, P
    Soressi, GP
    Pietta, PG
    [J]. ANNALS OF NUTRITION AND METABOLISM, 2003, 47 (02) : 64 - 69
  • [43] The Role of Hypoxia in Glioblastoma Invasion
    Monteiro, Ana Rita
    Hill, Richard
    Pilkington, Geoffrey J.
    Madureira, Patricia A.
    [J]. CELLS, 2017, 6 (04)
  • [44] Small Molecule Disruptors of the Glucokinase Glucokinase Regulatory Protein Interaction: 3. Structure Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N'-arylpiperazine Series
    Nishimura, Nobuko
    Norman, Mark H.
    Liu, Longbin
    Yang, Kevin C.
    Ashton, Kate S.
    Bartberger, Michael D.
    Chmait, Samer
    Chen, Jie
    Cupples, Rod
    Fotsch, Christopher
    Helmering, Joan
    Jordan, Steven R.
    Kunz, Roxanne K.
    Pennington, Lewis D.
    Poon, Steve F.
    Siegmund, Aaron
    Sivits, Glenn
    Lloyd, David J.
    Hale, Clarence
    St Jean, David J., Jr.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (07) : 3094 - 3116
  • [45] The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma
    Ou, Alexander
    Ott, Martina
    Fang, Dexing
    Heimberger, Amy B.
    [J]. CANCERS, 2021, 13 (03) : 1 - 25
  • [46] Current Understanding of Hypoxia in Glioblastoma Multiforme and Its Response to Immunotherapy
    Park, Jang Hyun
    Lee, Heung Kyu
    [J]. CANCERS, 2022, 14 (05)
  • [47] Sulfonylpiperazines based on a flavone as antioxidant and cytotoxic agents
    Patel, Rahul, V
    Mistry, Bhupendra M.
    Syed, Riyaz
    Parekh, Nikhil M.
    Shin, Han-Seung
    [J]. ARCHIV DER PHARMAZIE, 2019, 352 (09)
  • [48] Chrysin-piperazine conjugates as antioxidant and anticancer agents
    Patel, Rahul V.
    Mistry, Bhupendra
    Syed, Riyaz
    Rathi, Anuj K.
    Lee, Yoo-Jung
    Sung, Jung-Suk
    Shinf, Han-Seung
    Keum, Young-Soo
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 88 : 166 - 177
  • [49] qsarhub, PREADMET
  • [50] Targeting the JAK/STAT pathway in solid tumors
    Qureshy, Zoya
    Johnson, Daniel E.
    Grandis, Jennifer R.
    [J]. JOURNAL OF CANCER METASTASIS AND TREATMENT, 2020, 6