Novel synthesis naringenin-benzyl piperazine derivatives prevent glioblastoma invasion by inhibiting the hypoxia-induced IL6/JAK2/STAT3 axis and activating caspase-dependent apoptosis

被引：7
作者：
Zaim, Omer [1 ]
Doganlar, Oguzhan [2 ]
Doganlar, Zeynep Banu [2 ]
Ozcan, Hafize [1 ]
Zreigh, Mohamed M. [3 ]
Kurtdere, Kardelen [2 ]
机构：
[1] Trakya Univ, Dept Chem, TR-22030 Edirne, Turkey
[2] Trakya Univ, Fac Med, Dept Med Biol, TR-22030 Edirne, Turkey
[3] Zawia Univ, Fac Sci, Dept Chem, Zawia, Libya
来源：
BIOORGANIC CHEMISTRY | 2022年 / 129卷
关键词：
BIOLOGICAL EVALUATION; POOR-PROGNOSIS; CELLS; ANTIOXIDANT; EXPRESSION; FLAVONOIDS; MECHANISM; LINES; TOOL;
D O I：
10.1016/j.bioorg.2022.106209
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页数：11
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  • [1] Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners
    Abu-Aisheh, Marwa N.
    Mustafa, Mohammad S.
    El-Abadelah, Mustafa M.
    Naffa, Randa G.
    Ismail, Said I.
    Zihlif, Malek A.
    Taha, Mutasem O.
    Mubarak, Mohammad S.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 54 : 65 - 74
  • [2] PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside
    Alzahrani, Ali S.
    [J]. SEMINARS IN CANCER BIOLOGY, 2019, 59 : 125 - 132
  • [3] Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents
    Amujuri, Devi
    Siva, Bandi
    Poornima, B.
    Sirisha, Katukuri
    Sarma, A. V. S.
    Nayak, V. Lakshma
    Tiwari, Ashok K.
    Purushotham, U.
    Babu, K. Suresh
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 149 : 182 - 192
  • [4] Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms
    Arafah, Azher
    Rehman, Muneeb U.
    Mir, Tahir Maqbool
    Wali, Adil Farooq
    Ali, Rayeesa
    Qamar, Wajhul
    Khan, Rehan
    Ahmad, Ajaz
    Aga, Syed Sameer
    Alqahtani, Saeed
    Almatroudi, Nada M.
    [J]. PLANTS-BASEL, 2020, 9 (12):
  • [5] Synthesis and antimalarial evaluation of a series of piperazinyl flavones
    Auffret, Gwenola
    Labaied, Mehdi
    Frappier, Francois
    Rasoanaivo, Philippe
    Grellier, Philippe
    Lewin, Guy
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (04) : 959 - 963
  • [6] Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents
    Babu, KS
    Babu, TH
    Srinivas, PV
    Kishore, KH
    Murthy, USN
    Rao, JM
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (01) : 221 - 224
  • [7] Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents
    Bandgar, Babasaheb P.
    Patil, Sachin A.
    Gacche, Rajesh N.
    Korbad, Balaji L.
    Hote, Balwant S.
    Kinkar, Santosh N.
    Jalde, Shivkumar S.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (02) : 730 - 733
  • [8] The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
    Bao, Bin
    Azmi, Asfar S.
    Ali, Shadan
    Ahmad, Aamir
    Li, Yiwei
    Banerjee, Sanjeev
    Kong, Dejuan
    Sarkar, Fazlul H.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1826 (02): : 272 - 296
  • [9] Preparation and in vitro antioxidant activity of some novel flavone analogues bearing piperazine moiety
    Berczynski, Pawel
    Kladna, Aleksandra
    Dundar, Oya Bozdag
    Murat, Hatice Nehir
    Sari, Elmas
    Kruk, Irena
    Aboul-Enein, Hassan Y.
    [J]. BIOORGANIC CHEMISTRY, 2020, 95
  • [10] AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV
    Bhatt, Aadra P.
    Damania, Blossom
    [J]. FRONTIERS IN IMMUNOLOGY, 2013, 3
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