Intratubular germ cell neoplasia: Associated infertility and review of the diagnostic modalities

被引：4

作者：

Lifschitz-Mercer, B

Elliott, DJ

Schreiber-Bramante, L

Leider-Trejo, L

Eisenthal, A

Maymon, BB

机构：

[1] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, Inst Pathol, IL-64239 Tel Aviv, Israel

[2] Univ Newcastle, Inst Human Genet, Newcastle Upon Tyne, Tyne & Wear, England

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2001年 / 9卷 / 02期

关键词：

carcinoma in situ; diagnostic immunohistochemical markers; RBM gene expression; testicular neoplasia;

D O I：

10.1177/106689690100900202

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The incidence of testicular neoplasia has increased, and its early detection has become a pressing clinical issue. The strong association between male subfertility and risk of testicular neoplasia is consistent with the existence of common pathogenetic factors. Most forms of testicular germ tumors are believed to stem from a common precursor, intratubular germ cell neoplasia (ITGCN), also known as testicular carcinoma in situ. Identification of ITGCN cells in testicular biopsies, however, is a diagnostic challenge and markers are sorely needed to assist in the accurate identification of the lesion.

引用

页码：93 / 98

页数：6

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