Octreotide Delaying the Progression of Recurrent IgA Nephropathy After Kidney Transplantation

被引:2
|
作者
Sharma, Akhil [1 ]
Hariharan, Sundaram [1 ]
机构
[1] Univ Pittsburgh, Dept Med & Surg, Med Ctr, Pittsburgh, PA 15213 USA
来源
TRANSPLANTATION DIRECT | 2020年 / 6卷 / 01期
关键词
SOMATOSTATIN ANALOG; PATHOGENESIS; SMS-201-995; EXPRESSION; INSIGHTS;
D O I
10.1097/TXD.0000000000000963
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
IgA Nephropathy (IgAN) is a common cause of end-stage kidney disease worldwide. Unfortunately, the exact pathogenesis of IgAN remains uncertain without any targeted therapy. While kidney transplantation remains the gold standard treatment for those with end-stage kidney disease from IgAN, recurrence occurs frequently and may lead to early kidney transplant loss. Research has suggested that insulin-like growth factor-1 may play a role in mesangial cell proliferation in IgAN and Somatostatin may inhibit insulin-like growth factor-1. In this single case study, we report the use of octreotide, a somatostatin analogue, as a potential novel therapy for early recurrent IgAN post kidney transplant.
引用
收藏
页数:4
相关论文
共 50 条
  • [1] Urinary Uromodulin Excretion Predicts Progression of Chronic Kidney Disease Resulting from IgA Nephropathy
    Zhou, Jingjing
    Chen, Yuqing
    Liu, Ying
    Shi, Sufang
    Wang, Suxia
    Li, Xueying
    Zhang, Hong
    Wang, Haiyan
    PLOS ONE, 2013, 8 (08):
  • [2] Tonsillectomy Delays Progression of Advanced IgA Nephropathy to End-Stage Kidney Disease
    Komatsu, Hiroyuki
    Fujimoto, Shouichi
    Kikuchi, Masao
    Sato, Yuji
    Kitamura, Kazuo
    RENAL FAILURE, 2012, 34 (04) : 448 - 453
  • [3] An inflammatory cytokine signature predicts IgA nephropathy severity and progression
    Chen, Lei
    Chen, Xizhao
    Cai, Guangyan
    Jiang, Hongli
    Chen, Xiangmei
    Zhang, Min
    MEDCOMM, 2024, 5 (11):
  • [4] Transplantation of endothelial progenitor cells in treating rats with IgA nephropathy
    Guo, Wei
    Feng, Jiang-Min
    Yao, Li
    Sun, Li
    Zhu, Guang-Qing
    BMC NEPHROLOGY, 2014, 15
  • [5] Noninvasive Urinary Monitoring of Progression in IgA Nephropathy
    Yang, Joshua Y. C.
    Sarwal, Reuben D.
    Fervenza, Fernando C.
    Sarwal, Minnie M.
    Lafayette, Richard A.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (18)
  • [6] CD71 mesangial IgA1 receptor and the progression of IgA nephropathy
    Jhee, Jong Hyun
    Nam, Bo Young
    Park, Jung Tak
    Kim, Hyung Woo
    Chang, Tae Ik
    Kang, Ea Wha
    Lim, Beom Jin
    Yoo, Tae-Hyun
    Kang, Shin-Wook
    Jeong, Hyeon Joo
    Han, Seung Hyeok
    TRANSLATIONAL RESEARCH, 2021, 230 : 34 - 43
  • [7] The Association of Klotho Polymorphism with Disease Progression and Mortality in IgA Nephropathy
    Ko, Gang Jee
    Lee, Eun Ah
    Jeon, Un Sil
    Pyo, Heui Jung
    Chin, Ho Jun
    Chae, Dong Wan
    Kim, Suhnggwon
    Kwon, Young Joo
    KIDNEY & BLOOD PRESSURE RESEARCH, 2012, 36 (01) : 191 - 199
  • [8] Dyslipidemia may be a risk factor for progression in children with IgA nephropathy
    Zhuang, Hongjie
    Lin, Zhilang
    Zeng, Shuhan
    Jiang, Mengjie
    Chen, Lizhi
    Jiang, Xiaoyun
    Xu, Yuanyuan
    PEDIATRIC NEPHROLOGY, 2022, 37 (12) : 3147 - 3156
  • [9] Dietary Zinc Is a Key Environmental Modifier in the Progression of IgA Nephropathy
    Maiguma, Masayuki
    Suzuki, Yusuke
    Suzuki, Hitoshi
    Okazaki, Keiko
    Aizawa, Masashi
    Muto, Masahiro
    Tomino, Yasuhiko
    PLOS ONE, 2014, 9 (02):
  • [10] Is progression of IgA nephropathy conditioned by genes regulating atherosclerotic damage?
    Coppo, Rosanna
    Feehally, John
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (12) : 3573 - 3575