Bifunctional organocatalyst for methanolytic desymmetrization of cyclic anhydrides: increasing enantioselectivity by catalyst dilution

被引：112

作者：

Rho, Ho Sik ^{[2
,3
]}

Oh, Sang Ho ^{[3
]}

Lee, Ji Woong ^{[3
]}

Lee, Jin Yong ^{[3
]}

Chin, Jik ^{[1
]}

Song, Choong Eui ^{[3
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada

[2] AmorePacific Corp, R&D Ctr, Yongin 446729, South Korea

[3] Sungkyunkwan Univ, Dept Chem, Suwon 440746, Gyeonggi, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 10期

关键词：

D O I：

10.1039/b719811f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantioselective methanolysis of meso-cyclic anhydride was achieved with bifunctional organocatalyst containing a quinine-thiourea moiety; unusual concentration, temperature and solvent effects on the enantioselectivity can be explained in terms of a mechanism involving monomer-dimer equilibration of the catalyst.

引用

页码：1208 / 1210

页数：3

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