Micellar catalysis enabled synthesis of indolylbenzothiazoles and their functionalization via Mn(II)-catalyzed C2-H amination using pyridones

被引：7

作者：

Kumar, Sanjeev ^{[1
]}

Satpute, Dinesh Parshuram ^{[1
]}

Vaidya, Gargi Nikhil ^{[1
]}

Nagpure, Mithilesh ^{[1
]}

Lokhande, Shyam Kumar ^{[1
]}

Meena, Deepak ^{[1
]}

Kumar, Dinesh ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Gandhinagar 382355, Gujarat, India

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 25期

关键词：

Micellar catalysis; Indolylbenzothiazoles; Indole C-H amination; Manganese; Green chemistry; AQUEOUS-PHASE SYNTHESIS; C-H ARYLATION; BIOLOGICAL EVALUATION; ORGANIC-REACTIONS; INDOLES; WATER; BENZOTHIAZOLES; BENZIMIDAZOLES; INHIBITORS; DESIGN;

D O I：

10.1016/j.tetlet.2020.152017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The sustainable synthesis of indolylbenzothiazloes is reported utilising TPGS-750-M enabled nanomicellar catalysis in water. The reactions do not require additional catalysts and/or oxidants and proceed at room temperature. Subsequently, the indole rings were functionalized to construct novel tris-heterocyclic scaffolds via benzothiazole directed Mn(II)-catalyzed C-2-H amination utilizing pyridones as the amine partner. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：8

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