Publishing SNP Genotypes of Human Embryonic Stem Cell Lines: Policy Statement of the International Stem Cell Forum Ethics Working Party

被引：11

作者：

Knoppers, Bartha M. ^{[1
]}

Isasi, Rosario ^{[1
]}

Benvenisty, Nissim ^{[2
]}

Kim, Ock-Joo ^{[3
]}

Lomax, Geoffrey ^{[4
]}

Morris, Clive ^{[5
]}

Murray, Thomas H. ^{[6
]}

Lee, Eng Hin ^{[7
]}

Perry, Margery ^{[8
]}

Richardson, Genevra ^{[9
]}

Sipp, Douglas ^{[10
]}

Tanner, Klaus ^{[11
]}

Wahlstrom, Jan ^{[12
]}

de Wert, Guido ^{[13
]}

Zeng, Fanyi ^{[14
]}

机构：

[1] McGill Univ, Dept Human Genet, Fac Med, Int Stem Cell Forum Eth Working Party Ctr Genom &, Montreal, PQ H3A 1A4, Canada

[2] Hebrew Univ Jerusalem, Inst Life Sci, Herbert Cohn Chair Canc Res, Stem Cell Unit, IL-91904 Jerusalem, Israel

[3] Seoul Natl Univ, Coll Med, Dept Med Hist & Med Humanities, Seoul 110799, South Korea

[4] Calif Inst Regenerat Med, San Francisco, CA 94107 USA

[5] Natl Hlth & Med Res Council, Canberra, ACT 2601, Australia

[6] Hastings Ctr, Garrison, NY 10524 USA

[7] Natl Univ Singapore, Yong Loo Lin Sch Med, Fac Med, Div Grad Med Studies, Kent Ridge S117598, Singapore

[8] JDRF, Lay Review Comm, Aspen, CO 81612 USA

[9] Kings Coll London, Sch Law, London WC2R 2LS, England

[10] Riken Ctr Dev Biol, Sci Policy & Eth Studies Unit, Chuo Ku, Kobe, Hyogo 6500047, Japan

[11] Heidelberg Univ, Wissensch Theol Seminar, D-69117 Heidelberg, Germany

[12] Univ Gothenburg, Dept Med Genet, Klin Genet SU Sahlgrenska, S-41345 Gothenburg, Sweden

[13] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Hlth Eth & Soc, NL-6200 MD Maastricht, Netherlands

[14] Shanghai Jiao Tong Univ, Sch Med, Shanghai Stem Cell Inst, Shanghai Inst Med Genet, Shanghai 200025, Peoples R China

来源：

STEM CELL REVIEWS AND REPORTS | 2011年 / 7卷 / 03期

关键词：

Embryonic stem cells; Data sharing; Ethics; Policy; Databases; SNPs; Genotypic data;

D O I：

10.1007/s12015-010-9226-2

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Novel methods and associated tools permitting individual identification in publicly accessible SNP databases have become a debatable issue. There is growing concern that current technical and ethical safeguards to protect the identities of donors could be insufficient. In the context of human embryonic stem cell research, there are no studies focusing on the probability that an hESC line donor could be identified by analyzing published SNP profiles and associated genotypic and phenotypic information. We present the International Stem Cell Forum (ISCF) Ethics Working Party's Policy Statement on "Publishing SNP Genotypes of Human Embryonic Stem Cell Lines (hESC)". The Statement prospectively addresses issues surrounding the publication of genotypic data and associated annotations of hESC lines in open access databases. It proposes a balanced approach between the goals of open science and data sharing with the respect for fundamental bioethical principles (autonomy, privacy, beneficence, justice and research merit and integrity).

引用

页码：482 / 484

页数：3

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