Formulation and Evaluation of Rutin-Allicin Gel Against Diabetic Foot Ulcer

The purpose of this study was to prepare and evaluate a gel that is effective against non healing or resistant ulcers such as diabetic foot ulcers. A 20% w/v gel of each (rutin-allicin with optimized ratio 2:1) was made using Carbopol-940 in the concentration of 5% and evaluated for diabetic wounds. A total of 60 patients with partial thickness diabetic wound were divided into two equal groups. One group was treated with tetrachlorodecaoxide (TCDO) while the other with rutin allicin gel (RAG), and the results regarding the duration of wound epithelialization, wound contraction, pain relief, and cost of treatment were compared. In patients treated with RAG, healing of diabetic wounds was slightly earlier than those patients treated with TCDO (p < 0.05). All the patients of RAG treated group were relieved of pain earlier than those patients who were treated with TCDO furthermore, found cost effective as compared to TCDO. The results suggest that RAG possesses significant wound healing potential in chronic diabetic wounds and can be used as an effective, alternative, and cost effective medicine for wound care with unnoticeable toxicity.