Preparation and cytotoxic effect of ceanothic acid derivatives

被引：23

作者：

Lee, SS ^{[1
]}

Chen, WC

Huang, CF

Su, Y

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10018, Taiwan

[2] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 11期

关键词：

D O I：

10.1021/np9800856

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 mu g/mL, respectively, and an IC50 of 11.3 mu g/mL against normal cell line FS-5.

引用

页码：1343 / 1347

页数：5

共 8 条

[1] A MILD AND VERSATILE METHOD FOR CARBOXY GROUP ACTIVATION AND ESTERIFICATION [J].

CHANDRASEKARAN, S ;

TURNER, JV .

SYNTHETIC COMMUNICATIONS, 1982, 12 (09) :727-731

[2] NOTIZ UBER DIE SELEKTIVITAT DER SPALTUNG VON CARBONSAURE-METHYLESTERN MIT LITHIUMJODID [J].

ELSINGER, F ;

SCHREIBER, J ;

ESCHENMOSER, A .

HELVETICA CHIMICA ACTA, 1960, 43 (01) :113-118

[3] ANTI-AIDS AGENTS .11. BETULINIC ACID AND PLATANIC ACID AS ANTI-HIV PRINCIPLES FROM SYZIGIUM-CLAVIFLORUM, AND THE ANTI-HIV ACTIVITY OF STRUCTURALLY RELATED TRITERPENOIDS [J].

FUJIOKA, T ;

KASHIWADA, Y ;

KILKUSKIE, RE ;

COSENTINO, LM ;

BALLAS, LM ;

JIANG, JB ;

JANZEN, WP ;

CHEN, IS ;

LEE, KH .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (02) :243-247

[4] RE-EXAMINATION AND FURTHER DEVELOPMENT OF A PRECISE AND RAPID DYE METHOD FOR MEASURING CELL-GROWTH CELL KILL [J].

HANSEN, MB ;

NIELSEN, SE ;

BERG, K .

JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 119 (02) :203-210

[5] 2 NEW TRITERPENE GLUCOSIDES FROM PALIURUS-RAMOSISSIMUS [J].

LEE, SS ;

SU, WC ;

LIU, KC .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (02) :615-618

[6] 2 TRITERPENES FROM PALIURUS-RAMOSISSIMUS [J].

LEE, SS ;

LIN, CJ ;

LIU, KC .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (05) :602-606

[7]

LEE SS, 1992, J CHIN CHEM SOC-TAIP, V40, P213

[8] DISCOVERY OF BETULINIC ACID AS A SELECTIVE INHIBITOR OF HUMAN-MELANOMA THAT FUNCTIONS BY INDUCTION OF APOPTOSIS [J].

PISHA, E ;

CHAI, H ;

LEE, IS ;

CHAGWEDERA, TE ;

FARNSWORTH, NR ;

CORDELL, GA ;

BEECHER, CWW ;

FONG, HHS ;

KINGHORN, AD ;

BROWN, DM ;

WANI, MC ;

WALL, ME ;

HIEKEN, TJ ;

DASGUPTA, TK ;

PEZZUTO, JM .

NATURE MEDICINE, 1995, 1 (10) :1046-1051

← 1 →