CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses

被引：45
作者：
Barouch, DH
Letvin, NL
机构：
[1] Harvard Univ, Sch Med, Boston, MA 02215 USA
[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 04期
关键词：
D O I：
10.1016/S0952-7915(00)00244-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune containment of persistent viral infections has long been a focus of interest for investigators. However, the technologies needed to evaluate the role of CD8(+) cytotoxic T lymphocytes (CTLs) in this process have only recently become available. Recent studies performed using tetramer, ELISPOT and cytokine-production assays have evaluated the role of CD8(+) CTLs in controlling lentivirus and herpesvirus infections in humans and nonhuman primates. These studies demonstrate dramatic expansions of virus-specific CTLs in primary infection and the maintenance of unexpectedly high levels of virus-specific CTLs in chronic infection. These findings underscore the importance of CD8(+) CTLs in the immune control of persistent viral infections.
引用
收藏
页码：479 / 482
页数：4
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