CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses

被引：45

作者：

Barouch, DH

Letvin, NL

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00244-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune containment of persistent viral infections has long been a focus of interest for investigators. However, the technologies needed to evaluate the role of CD8(+) cytotoxic T lymphocytes (CTLs) in this process have only recently become available. Recent studies performed using tetramer, ELISPOT and cytokine-production assays have evaluated the role of CD8(+) CTLs in controlling lentivirus and herpesvirus infections in humans and nonhuman primates. These studies demonstrate dramatic expansions of virus-specific CTLs in primary infection and the maintenance of unexpectedly high levels of virus-specific CTLs in chronic infection. These findings underscore the importance of CD8(+) CTLs in the immune control of persistent viral infections.

引用

收藏

页码：479 / 482

页数：4

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