CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses

被引：45

作者：

Barouch, DH

Letvin, NL

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00244-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune containment of persistent viral infections has long been a focus of interest for investigators. However, the technologies needed to evaluate the role of CD8(+) cytotoxic T lymphocytes (CTLs) in this process have only recently become available. Recent studies performed using tetramer, ELISPOT and cytokine-production assays have evaluated the role of CD8(+) CTLs in controlling lentivirus and herpesvirus infections in humans and nonhuman primates. These studies demonstrate dramatic expansions of virus-specific CTLs in primary infection and the maintenance of unexpectedly high levels of virus-specific CTLs in chronic infection. These findings underscore the importance of CD8(+) CTLs in the immune control of persistent viral infections.

引用

页码：479 / 482

页数：4

共 45 条

[1] Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection [J].

Altfeld, M ;

Rosenberg, ES ;

Shankarappa, R ;

Mukherjee, JS ;

Hecht, FM ;

Eldridge, RL ;

Addo, MM ;

Poon, SH ;

Phillips, MN ;

Robbins, GK ;

Sax, PE ;

Boswell, S ;

Kahn, JO ;

Brander, C ;

Goulder, PJR ;

Levy, JA ;

Mullins, JI ;

Walker, BD .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (02) :169-180

[2] Phenotypic analysis of antigen-specific T lymphocytes [J].

Altman, JD ;

Moss, PAH ;

Goulder, PJR ;

Barouch, DH ;

McHeyzerWilliams, MG ;

Bell, JI ;

McMichael, AJ ;

Davis, MM .

SCIENCE, 1996, 274 (5284) :94-96

[3] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

Miller, J ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

SCIENCE, 2001, 292 (5514) :69-74

[4] Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys [J].

Barouch, DH ;

Craiu, A ;

Kuroda, MJ ;

Schmitz, JE ;

Zheng, XX ;

Santra, S ;

Frost, JD ;

Krivulka, GR ;

Lifton, MA ;

Crabbs, CL ;

Heidecker, G ;

Perry, HC ;

Davies, ME ;

Xie, H ;

Nickerson, CE ;

Steenbeke, TD ;

Lord, CI ;

Montefiori, DC ;

Strom, TB ;

Shiver, JW ;

Lewis, MG ;

Letvin, NL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4192-4197

[5] Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination [J].

Barouch, DH ;

Santra, S ;

Schmitz, JE ;

Kuroda, MJ ;

Fu, TM ;

Wagner, W ;

Bilska, M ;

Craiu, A ;

Zheng, XX ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Nickerson, CE ;

Trigona, WL ;

Punt, K ;

Freed, DC ;

Guan, LM ;

Dubey, S ;

Casimiro, D ;

Simon, A ;

Davies, ME ;

Chastain, M ;

Strom, TB ;

Gelman, RS ;

Montefiori, DC ;

Lewis, MG ;

Emini, EA ;

Shiver, JW ;

Letvin, NL .

SCIENCE, 2000, 290 (5491) :486-492

[6] Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination [J].

Barouch, DH ;

Santra, S ;

Kuroda, MJ ;

Schmitz, JE ;

Plishka, R ;

Buckler-White, A ;

Gaitan, AE ;

Zin, R ;

Nam, JH ;

Wyatt, LS ;

Lifton, MA ;

Nickerson, CE ;

Moss, B ;

Montefiori, DC ;

Hirsch, VM ;

Letvin, NL .

JOURNAL OF VIROLOGY, 2001, 75 (11) :5151-5158

[7] New methods for assessing T-Cell responses [J].

Bercovici, N ;

Duffour, MT ;

Agrawal, S ;

Salcedo, M ;

Abastado, JP .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2000, 7 (06) :859-864

[8] VIRUS-SPECIFIC CD8+ CYTOTOXIC T-LYMPHOCYTE ACTIVITY ASSOCIATED WITH CONTROL OF VIREMIA IN PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].

BORROW, P ;

LEWICKI, H ;

HAHN, BH ;

SHAW, GM ;

OLDSTONE, MBA .

JOURNAL OF VIROLOGY, 1994, 68 (09) :6103-6110

[9] Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo [J].

Callan, MFC ;

Tan, L ;

Annels, N ;

Ogg, GS ;

Wilson, JDK ;

O'Callaghan, CA ;

Steven, N ;

McMichael, AJ ;

Rickinson, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (09) :1395-1402

[10] Large clonal expansions of CD8(+) T cells in acute infectious mononucleosis [J].

Callan, MFC ;

Steven, J ;

Krausa, P ;

Wilson, JDK ;

Moss, PAH ;

Gillespie, GM ;

Bell, JI ;

Rickinson, AB ;

McMichael, AJ .

NATURE MEDICINE, 1996, 2 (08) :906-911

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