Is lysozyme really the ideal model protein?

被引：23
作者：
Chayen, NE [1 ]
Saridakis, E [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, Biol Struct & Funct Sect, London SW7 2AZ, England
来源：
JOURNAL OF CRYSTAL GROWTH | 2001年 / 232卷 / 1-4期
关键词：
biocrystallization; nucleation; surfaces; biological macromolecules; lysozyme; proteins;
D O I：
10.1016/S0022-0248(01)01203-9
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
A series of potential heterogeneous nucleants were added to metastable solutions of lysozyme and of four other model proteins, as well as to a few target proteins. Some of the substances markedly affected the nucleation of lysozyme crystals, but did not influence the other proteins. The results for other proteins were disappointing because these nucleants have not turned out to be the universal nucleants we were hoping for. However, having worked so well for lysozyme, they may yet prove useful in individual cases. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：262 / 264
页数：3
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