Signal-Pair Correlation Analysis of Single-Molecule Trajectories

被引：23
|
作者：
Hoffmann, Armin [1 ,2 ]
Woodside, Michael T. [1 ,2 ]
机构：
[1] Univ Alberta, Dept Phys, Edmonton, AB T6G 2M9, Canada
[2] NRC, Natl Inst Nanotechnol, Edmonton, AB T6G 2M9, Canada
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 52期
关键词：
biophysics; kinetics; single-molecule studies; PROTEIN; CHANNEL; FRET;
D O I：
10.1002/anie.201104033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
There you go: How to get kinetic information from trajectories of single biomolecules? A method based on correlating signal ranges (here for a three-state DNA hairpin with F=folded, I= intermediate, and U=unfolded state) is reported and shows how to get the kinetic scheme and the corresponding rates, even for states with low occupancy or very short lifetime, states which overlap because of noise, and systems with very similar or very different rates. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12643 / 12646
页数：4
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